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Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Patients: A Resting-State fMRI Study

Overview of attention for article published in Frontiers in Aging Neuroscience, March 2018
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Title
Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Patients: A Resting-State fMRI Study
Published in
Frontiers in Aging Neuroscience, March 2018
DOI 10.3389/fnagi.2018.00055
Pubmed ID
Authors

Daihong Liu, Shanshan Duan, Chaoyang Zhou, Ping Wei, Lihua Chen, Xuntao Yin, Jiuquan Zhang, Jian Wang

Abstract

Type 2 diabetes mellitus (T2DM) affects a vast population and is closely associated with cognitive impairment. However, the mechanisms of cognitive impairment in T2DM patients have not been unraveled. Research on the basic units (nodes or hubs and edges) of the brain functional network on the basis of neuroimaging may advance our understanding of the network change pattern in T2DM patients. This study investigated the change patterns of brain functional hubs using degree centrality (DC) analysis and the connectivity among these hubs using functional connectivity and Granger causality analysis. Compared to healthy controls, the DC values were higher in the left anterior cingulate gyrus (ACG) and lower in the bilateral lateral occipital cortices (LOC) and right precentral gyrus (PreCG) in T2DM patients. The functional connectivity between the left ACG and the right PreCG was stronger in T2DM patients, whereas the functional connectivity among the right PreCG and bilateral LOC was weaker. A negative causal effect from the left ACG to left LOC and a positive effect from the left ACG to right LOC were observed in T2DM patients, while in healthy controls, the opposite occurred. Additionally, the reserve of normal brain function in T2DM patients was negatively associated with the elevated glycemic parameters. This study demonstrates that there are brain functional hubs and connectivity alterations that may reflect the aberrant information communication in the brain of T2DM patients. The findings may advance our understanding of the mechanisms of T2DM-related cognitive impairment.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 15%
Student > Ph. D. Student 6 13%
Researcher 5 10%
Student > Bachelor 4 8%
Lecturer 3 6%
Other 8 17%
Unknown 15 31%
Readers by discipline Count As %
Medicine and Dentistry 6 13%
Neuroscience 6 13%
Psychology 6 13%
Agricultural and Biological Sciences 3 6%
Nursing and Health Professions 2 4%
Other 5 10%
Unknown 20 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2018.
All research outputs
#20,468,008
of 23,026,672 outputs
Outputs from Frontiers in Aging Neuroscience
#4,343
of 4,846 outputs
Outputs of similar age
#293,401
of 331,979 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#101
of 108 outputs
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