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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Gray/White Matter Contrast in Parkinson’s Disease
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, March 2018
|
| DOI | 10.3389/fnagi.2018.00089 |
| Pubmed ID | |
| Authors |
Carme Uribe, Barbara Segura, Hugo C. Baggio, Alexandra Abos, Anna I. Garcia-Diaz, Anna Campabadal, Maria J. Marti, Francesc Valldeoriola, Yaroslau Compta, Nuria Bargallo, Carme Junque |
| Abstract |
Gray/white matter contrast (GWC) decreases with aging and has been found to be a useful MRI biomarker in Alzheimer's disease (AD), but its utility in Parkinson's disease (PD) patients has not been investigated. The aims of the study were to test whether GWC is sensitive to aging changes in PD patients, if PD patients differ from healthy controls (HCs) in GWC, and whether the use of GWC data would improve the sensitivity of cortical thickness analyses to differentiate PD patients from controls. Using T1-weighted structural images, we obtained individual cortical thickness and GWC values from a sample of 90 PD patients and 27 controls. Images were processed with the automated FreeSurfer stream. GWC was computed by dividing the white matter (WM) by the gray matter (GM) values and projecting the ratios onto a common surface. The sample characteristics were: 52 patients and 14 controls were males; mean age of 64.4 ± 10.6 years in PD and 64.7 ± 8.6 years in controls; 8.0 ± 5.6 years of disease evolution; 15.6 ± 9.8 UPDRS; and a range of 1.5-3 in Hoehn and Yahr (H&Y) stage. In both PD and controls we observed significant correlations between GWC and age involving almost the entire cortex. When applying a stringent cluster-forming threshold of p < 0.0001, the correlation between GWC and age also involved the entire cortex in the PD group; in the control group, the correlation was found in the parahippocampal gyrus and widespread frontal and parietal areas. The GWC of PD patients did not differ from controls', whereas cortical thickness analyses showed thinning in temporal and parietal cortices in the PD group. Cortical thinning remained unchanged after adjusting for GWC. GWC is a very sensitive measure for detecting aging effects, but did not provide additional information over other parameters of atrophy in PD. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 17% |
| Australia | 1 | 17% |
| Puerto Rico | 1 | 17% |
| United Kingdom | 1 | 17% |
| Switzerland | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Scientists | 2 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 48 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 15% |
| Student > Doctoral Student | 6 | 13% |
| Researcher | 6 | 13% |
| Student > Master | 6 | 13% |
| Student > Bachelor | 5 | 10% |
| Other | 9 | 19% |
| Unknown | 9 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 10 | 21% |
| Neuroscience | 6 | 13% |
| Medicine and Dentistry | 5 | 10% |
| Engineering | 4 | 8% |
| Computer Science | 3 | 6% |
| Other | 9 | 19% |
| Unknown | 11 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2018.
All research outputs
#2,581,431
of 23,028,364 outputs
Outputs from Frontiers in Aging Neuroscience
#887
of 4,847 outputs
Outputs of similar age
#56,284
of 330,024 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#34
of 108 outputs
Altmetric has tracked 23,028,364 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,847 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,024 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.