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Cerebrovascular-Reactivity Mapping Using MRI: Considerations for Alzheimer’s Disease

Overview of attention for article published in Frontiers in Aging Neuroscience, June 2018
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Title
Cerebrovascular-Reactivity Mapping Using MRI: Considerations for Alzheimer’s Disease
Published in
Frontiers in Aging Neuroscience, June 2018
DOI 10.3389/fnagi.2018.00170
Pubmed ID
Authors

J. J. Chen

Abstract

Alzheimer's disease (AD) is associated with well-established macrostructural and cellular markers, including localized brain atrophy and deposition of amyloid. However, there is growing recognition of the link between cerebrovascular dysfunction and AD, supported by continuous experimental evidence in the animal and human literature. As a result, neuroimaging studies of AD are increasingly aiming to incorporate vascular measures, exemplified by measures of cerebrovascular reactivity (CVR). CVR is a measure that is rooted in clinical practice, and as non-invasive CVR-mapping techniques become more widely available, routine CVR mapping may open up new avenues of investigation into the development of AD. This review focuses on the use of MRI to map CVR, paying specific attention to recent developments in MRI methodology and on the emerging stimulus-free approaches to CVR mapping. It also summarizes the biological basis for the vascular contribution to AD, and provides critical perspective on the choice of CVR-mapping techniques amongst frail populations.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 64 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 16%
Student > Ph. D. Student 8 13%
Student > Master 8 13%
Student > Bachelor 4 6%
Professor 4 6%
Other 10 16%
Unknown 20 31%
Readers by discipline Count As %
Neuroscience 8 13%
Medicine and Dentistry 7 11%
Engineering 5 8%
Psychology 5 8%
Computer Science 3 5%
Other 9 14%
Unknown 27 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2018.
All research outputs
#14,130,357
of 23,088,369 outputs
Outputs from Frontiers in Aging Neuroscience
#3,141
of 4,867 outputs
Outputs of similar age
#179,982
of 329,782 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#85
of 109 outputs
Altmetric has tracked 23,088,369 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,867 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,782 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.