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Non-invasive Brain Stimulation: Probing Intracortical Circuits and Improving Cognition in the Aging Brain

Overview of attention for article published in Frontiers in Aging Neuroscience, June 2018
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  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Average Attention Score compared to outputs of the same age and source

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Title
Non-invasive Brain Stimulation: Probing Intracortical Circuits and Improving Cognition in the Aging Brain
Published in
Frontiers in Aging Neuroscience, June 2018
DOI 10.3389/fnagi.2018.00177
Pubmed ID
Authors

Joyce Gomes-Osman, Aprinda Indahlastari, Peter J. Fried, Danylo L. F. Cabral, Jordyn Rice, Nicole R. Nissim, Serkan Aksu, Molly E. McLaren, Adam J. Woods

Abstract

The impact of cognitive aging on brain function and structure is complex, and the relationship between aging-related structural changes and cognitive function are not fully understood. Physiological and pathological changes to the aging brain are highly variable, making it difficult to estimate a cognitive trajectory with which to monitor the conversion to cognitive decline. Beyond the information on the structural and functional consequences of cognitive aging gained from brain imaging and neuropsychological studies, non-invasive brain stimulation techniques such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) can enable stimulation of the human brain in vivo, offering useful insights into the functional integrity of intracortical circuits using electrophysiology and neuromodulation. TMS measurements can be used to identify and monitor changes in cortical reactivity, the integrity of inhibitory and excitatory intracortical circuits, the mechanisms of long-term potentiation (LTP)/depression-like plasticity and central cholinergic function. Repetitive TMS and tDCS can be used to modulate neuronal excitability and enhance cortical function, and thus offer a potential means to slow or reverse cognitive decline. This review will summarize and critically appraise relevant literature regarding the use of TMS and tDCS to probe cortical areas affected by the aging brain, and as potential therapeutic tools to improve cognitive function in the aging population. Challenges arising from intra-individual differences, limited reproducibility, and methodological differences will be discussed.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 153 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 16%
Researcher 19 12%
Student > Bachelor 14 9%
Student > Doctoral Student 12 8%
Student > Master 10 7%
Other 24 16%
Unknown 49 32%
Readers by discipline Count As %
Neuroscience 34 22%
Psychology 20 13%
Medicine and Dentistry 12 8%
Nursing and Health Professions 6 4%
Agricultural and Biological Sciences 4 3%
Other 14 9%
Unknown 63 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2018.
All research outputs
#12,906,201
of 23,090,520 outputs
Outputs from Frontiers in Aging Neuroscience
#2,754
of 4,867 outputs
Outputs of similar age
#154,685
of 328,957 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#73
of 109 outputs
Altmetric has tracked 23,090,520 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,867 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,957 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.