Title |
Study Protocol for a Randomized Controlled Trial of Choral Singing Intervention to Prevent Cognitive Decline in At-Risk Older Adults Living in the Community
|
---|---|
Published in |
Frontiers in Aging Neuroscience, July 2018
|
DOI | 10.3389/fnagi.2018.00195 |
Pubmed ID | |
Authors |
Jasmine Tan, F. H. Maurine Tsakok, Elisabeth K. Ow, Bernard Lanskey, Kian Siong Darius Lim, Lee Gan Goh, Chay-Hoon Tan, Irwin Kee-Mun Cheah, Anis Larbi, Roger Foo, Marie Loh, Caroline Kai Yun Wong, John Suckling, Jialiang Li, Rathi Mahendran, Ee-Heok Kua, Lei Feng |
Abstract |
Introduction: This study is a parallel-arm randomized controlled trial evaluating choral singing's efficacy and underlying mechanisms in preventing cognitive decline in at-risk older participants. Methods: Three-hundred and sixty community-dwelling, non-demented older participants are recruited for a 2-year intervention. Inclusion criteria are self-reported cognitive complaints, early cognitive impairment based on neuropsychological test scores or multiple risk factors of dementia. Participants are randomized to either weekly choral singing sessions or general health education. The primary outcome is cognitive performance, measured by a composite cognitive test score (CCTS). Secondary outcomes include depression, anxiety and neuropsychiatric symptoms; perceived stress; sleep quality and severity of dementia symptoms. Underlying mechanisms are examined using blood- and urine-based biomarkers and neuroimaging. Results: Screening began in July 2016. The first group of participants (n = 93) have been recruited. Intervention and control treatments are ongoing and will end in December 2019. Discussion: An evidence-based singing intervention for dementia prevention holds potential for healthcare savings and societal welfare. Trial Registration: NCT02919748, IRB Approval Number: NUS 2508. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Turkey | 7 | 29% |
United Kingdom | 4 | 17% |
United States | 1 | 4% |
Australia | 1 | 4% |
Switzerland | 1 | 4% |
Unknown | 10 | 42% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 18 | 75% |
Scientists | 3 | 13% |
Practitioners (doctors, other healthcare professionals) | 3 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 157 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 25 | 16% |
Student > Ph. D. Student | 23 | 15% |
Student > Bachelor | 13 | 8% |
Researcher | 12 | 8% |
Student > Doctoral Student | 5 | 3% |
Other | 19 | 12% |
Unknown | 60 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 26 | 17% |
Nursing and Health Professions | 17 | 11% |
Social Sciences | 12 | 8% |
Medicine and Dentistry | 10 | 6% |
Neuroscience | 7 | 4% |
Other | 21 | 13% |
Unknown | 64 | 41% |