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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Systemic Inflammation Mediates Age-Related Cognitive Deficits
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, August 2018
|
| DOI | 10.3389/fnagi.2018.00236 |
| Pubmed ID | |
| Authors |
Tian Lin, Gene A. Liu, Eliany Perez, Robert D. Rainer, Marcelo Febo, Yenisel Cruz-Almeida, Natalie C. Ebner |
| Abstract |
The association between systemic inflammation and cognitive deficits is well-documented. Further, previous studies have shown that systemic inflammation levels increase with age. The present study took a novel approach by examining the extent to which systemic inflammation levels mediated age-related cognitive decline. Forty-seven young and 46 older generally healthy adults completed two cognitive tasks measuring processing speed and short-term memory, respectively. Serum concentrations of three inflammatory biomarkers (including interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP)) were measured in each participant. Both cognitive measures showed age-related deficits. In addition, levels of IL-6 and TNF-α were elevated with age. IL-6 partially mediated the difference in processing speed between the young and the older participant age group; there was no mediation effect for TNF-α and CRP. Considering chronological age, IL-6 partially accounted for age-related impairment in processing speed within older but not young participants. No effects were found for short-term memory. Evidence from this research supports the role of inflammatory processes in age-related cognitive decline. Processes involved in this mediation and differences in inflammatory influence on specific cognitive functions are discussed. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 17% |
| France | 1 | 6% |
| Australia | 1 | 6% |
| Thailand | 1 | 6% |
| Unknown | 12 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 50% |
| Scientists | 8 | 44% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 118 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 24 | 20% |
| Student > Ph. D. Student | 11 | 9% |
| Student > Doctoral Student | 11 | 9% |
| Researcher | 10 | 8% |
| Other | 9 | 8% |
| Other | 23 | 19% |
| Unknown | 30 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 19 | 16% |
| Psychology | 15 | 13% |
| Biochemistry, Genetics and Molecular Biology | 12 | 10% |
| Medicine and Dentistry | 7 | 6% |
| Nursing and Health Professions | 4 | 3% |
| Other | 21 | 18% |
| Unknown | 40 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2020.
All research outputs
#992,591
of 23,415,749 outputs
Outputs from Frontiers in Aging Neuroscience
#200
of 4,912 outputs
Outputs of similar age
#22,834
of 331,493 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#9
of 90 outputs
Altmetric has tracked 23,415,749 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,912 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,493 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.