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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cognitive Reserve Relates to Functional Network Efficiency in Alzheimer’s Disease
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, August 2018
|
| DOI | 10.3389/fnagi.2018.00255 |
| Pubmed ID | |
| Authors |
Marina Weiler, Raphael Fernandes Casseb, Brunno Machado de Campos, Camila Vieira de Ligo Teixeira, Ana Flávia Mac Knight Carletti-Cassani, Jéssica Elias Vicentini, Thamires Naela Cardoso Magalhães, Débora Queiroz de Almeira, Leda Leme Talib, Orestes Vicente Forlenza, Marcio Luiz Figueredo Balthazar, Gabriela Castellano |
| Abstract |
Alzheimer's disease (AD) is the most common form of dementia, with no means of cure or prevention. The presence of abnormal disease-related proteins in the population is, in turn, much more common than the incidence of dementia. In this context, the cognitive reserve (CR) hypothesis has been proposed to explain the discontinuity between pathophysiological and clinical expression of AD, suggesting that CR mitigates the effects of pathology on clinical expression and cognition. fMRI studies of the human connectome have recently reported that AD patients present diminished functional efficiency in resting-state networks, leading to a loss in information flow and cognitive processing. No study has investigated, however, whether CR modifies the effects of the pathology in functional network efficiency in AD patients. We analyzed the relationship between CR, pathophysiology and network efficiency, and whether CR modifies the relationship between them. Fourteen mild AD, 28 amnestic mild cognitive impairment (aMCI) due to AD, and 28 controls were enrolled. We used education to measure CR, cerebrospinal fluid (CSF) biomarkers to evaluate pathophysiology, and graph metrics to measure network efficiency. We found no relationship between CR and CSF biomarkers; CR was related to higher network efficiency in all groups; and abnormal levels of CSF protein biomarkers were related to more efficient networks in the AD group. Education modified the effects of tau-related pathology in the aMCI and mild AD groups. Although higher CR might not protect individuals from developing AD pathophysiology, AD patients with higher CR are better able to cope with the effects of pathology-presenting more efficient networks despite pathology burden. The present study highlights that interventions focusing on cognitive stimulation might be useful to slow age-related cognitive decline or dementia and lengthen healthy aging. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 101 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 12% |
| Student > Bachelor | 12 | 12% |
| Researcher | 10 | 10% |
| Student > Doctoral Student | 9 | 9% |
| Student > Ph. D. Student | 7 | 7% |
| Other | 20 | 20% |
| Unknown | 31 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 21 | 21% |
| Medicine and Dentistry | 11 | 11% |
| Psychology | 11 | 11% |
| Social Sciences | 4 | 4% |
| Nursing and Health Professions | 3 | 3% |
| Other | 14 | 14% |
| Unknown | 37 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2018.
All research outputs
#2,647,438
of 23,100,534 outputs
Outputs from Frontiers in Aging Neuroscience
#971
of 4,871 outputs
Outputs of similar age
#55,685
of 333,760 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#31
of 102 outputs
Altmetric has tracked 23,100,534 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,871 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,760 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 102 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.