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Stereological Assessments of Neuronal Pathology in Auditory Cortex in Schizophrenia

Overview of attention for article published in Frontiers in Neuroanatomy, January 2018
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Title
Stereological Assessments of Neuronal Pathology in Auditory Cortex in Schizophrenia
Published in
Frontiers in Neuroanatomy, January 2018
DOI 10.3389/fnana.2017.00131
Pubmed ID
Authors

Emily M. Parker, Robert A. Sweet

Abstract

It has long been known that auditory processing is disrupted in schizophrenia. More recently, postmortem studies have provided direct evidence that morphological alterations to neurons in auditory cortex are implicated in the pathophysiology of this illness, confirming previous predictions. Potential neural substrates for auditory impairment and gray matter loss in auditory cortex in schizophrenia have been identified, described, and are the focus of this review article. Pyramidal cell somal volume is reduced in auditory cortex, as are dendritic spine density and number in schizophrenia. Pyramidal cells are not lost in this region in schizophrenia, indicating that dendritic spine reductions reflect fewer spines per pyramidal cell, consistent with the reduced neuropil hypothesis of schizophrenia. Stereological methods have aided in the proper collection, reporting and interpretation of this data. Mechanistic studies exploring relationships between genetic risk for schizophrenia and altered dendrite morphology represent an important avenue for future research in order to further elucidate cellular pathology in auditory cortex in schizophrenia.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 17%
Researcher 6 11%
Student > Bachelor 6 11%
Professor 4 7%
Student > Doctoral Student 2 4%
Other 9 17%
Unknown 18 33%
Readers by discipline Count As %
Neuroscience 15 28%
Agricultural and Biological Sciences 5 9%
Psychology 3 6%
Nursing and Health Professions 2 4%
Engineering 2 4%
Other 7 13%
Unknown 20 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2018.
All research outputs
#20,901,837
of 26,556,730 outputs
Outputs from Frontiers in Neuroanatomy
#947
of 1,289 outputs
Outputs of similar age
#334,869
of 457,827 outputs
Outputs of similar age from Frontiers in Neuroanatomy
#31
of 41 outputs
Altmetric has tracked 26,556,730 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,289 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 457,827 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.