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Mendeley readers
Attention Score in Context
| Title |
Deep brain stimulation of the ventral striatum increases BDNF in the fear extinction circuit
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, January 2013
|
| DOI | 10.3389/fnbeh.2013.00102 |
| Pubmed ID | |
| Authors |
Fabricio H. Do-Monte, Jose Rodriguez-Romaguera, Luis E. Rosas-Vidal, Gregory J. Quirk |
| Abstract |
Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) reduces the symptoms of treatment-resistant obsessive compulsive disorder (OCD), and improves response to extinction-based therapies. We recently reported that DBS-like stimulation of a rat homologue of VC/VS, the dorsal-VS, reduced conditioned fear and enhanced extinction memory (Rodriguez-Romaguera et al., 2012). In contrast, DBS of the ventral-VS had the opposite effects. To examine possible mechanisms of these effects, we assessed the effects of VS DBS on the expression of the neural activity marker Fos and brain-derived neurotrophic factor (BDNF), a key mediator of extinction plasticity in prefrontal-amygdala circuits. Consistent with decreased fear expression, DBS of dorsal-VS increased Fos expression in prelimbic and infralimbic prefrontal cortices and in the lateral division of the central nucleus of amygdala, an area that inhibits amygdala output. Consistent with improved extinction memory, we found that DBS of dorsal-VS, but not ventral-VS, increased neuronal BDNF expression in prelimbic and infralimbic prefrontal cortices. These rodent findings are consistent with the idea that clinical DBS of VC/VS may augment fear extinction through an increase in BDNF expression. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| China | 1 | <1% |
| France | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 96 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 34% |
| Researcher | 18 | 18% |
| Student > Bachelor | 9 | 9% |
| Student > Master | 7 | 7% |
| Other | 5 | 5% |
| Other | 14 | 14% |
| Unknown | 14 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 30 | 29% |
| Agricultural and Biological Sciences | 17 | 17% |
| Medicine and Dentistry | 13 | 13% |
| Psychology | 10 | 10% |
| Engineering | 4 | 4% |
| Other | 6 | 6% |
| Unknown | 22 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2013.
All research outputs
#17,691,546
of 22,715,151 outputs
Outputs from Frontiers in Behavioral Neuroscience
#2,401
of 3,150 outputs
Outputs of similar age
#210,190
of 280,748 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#113
of 165 outputs
Altmetric has tracked 22,715,151 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,150 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.2. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,748 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 165 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.