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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Medial prefrontal cortex stimulation modulates the processing of conditioned fear
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, January 2014
|
| DOI | 10.3389/fnbeh.2014.00044 |
| Pubmed ID | |
| Authors |
Anne Guhn, Thomas Dresler, Marta Andreatta, Laura D. Müller, Tim Hahn, Sara V. Tupak, Thomas Polak, Jürgen Deckert, Martin J. Herrmann |
| Abstract |
The extinction of conditioned fear depends on an efficient interplay between the amygdala and the medial prefrontal cortex (mPFC). In rats, high-frequency electrical mPFC stimulation has been shown to improve extinction by means of a reduction of amygdala activity. However, so far it is unclear whether stimulation of homologues regions in humans might have similar beneficial effects. Healthy volunteers received one session of either active or sham repetitive transcranial magnetic stimulation (rTMS) covering the mPFC while undergoing a 2-day fear conditioning and extinction paradigm. Repetitive TMS was applied offline after fear acquisition in which one of two faces (CS+ but not CS-) was associated with an aversive scream (UCS). Immediate extinction learning (day 1) and extinction recall (day 2) were conducted without UCS delivery. Conditioned responses (CR) were assessed in a multimodal approach using fear-potentiated startle (FPS), skin conductance responses (SCR), functional near-infrared spectroscopy (fNIRS), and self-report scales. Consistent with the hypothesis of a modulated processing of conditioned fear after high-frequency rTMS, the active group showed a reduced CS+/CS- discrimination during extinction learning as evident in FPS as well as in SCR and arousal ratings. FPS responses to CS+ further showed a linear decrement throughout both extinction sessions. This study describes the first experimental approach of influencing conditioned fear by using rTMS and can thus be a basis for future studies investigating a complementation of mPFC stimulation to cognitive behavioral therapy (CBT). |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 155 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 2 | 1% |
| Hungary | 1 | <1% |
| Germany | 1 | <1% |
| France | 1 | <1% |
| Netherlands | 1 | <1% |
| Brazil | 1 | <1% |
| Canada | 1 | <1% |
| New Zealand | 1 | <1% |
| Singapore | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 144 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 20% |
| Researcher | 27 | 17% |
| Student > Master | 18 | 12% |
| Student > Bachelor | 18 | 12% |
| Student > Doctoral Student | 10 | 6% |
| Other | 25 | 16% |
| Unknown | 26 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 49 | 32% |
| Neuroscience | 31 | 20% |
| Medicine and Dentistry | 15 | 10% |
| Agricultural and Biological Sciences | 11 | 7% |
| Nursing and Health Professions | 4 | 3% |
| Other | 8 | 5% |
| Unknown | 37 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2014.
All research outputs
#15,296,915
of 22,749,166 outputs
Outputs from Frontiers in Behavioral Neuroscience
#2,211
of 3,157 outputs
Outputs of similar age
#189,987
of 305,221 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#42
of 56 outputs
Altmetric has tracked 22,749,166 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,157 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.2. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,221 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.