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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Pain-related stress during the Neonatal Intensive Care Unit stay and SLC6A4 methylation in very preterm infants
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, April 2015
|
| DOI | 10.3389/fnbeh.2015.00099 |
| Pubmed ID | |
| Authors |
Livio Provenzi, Monica Fumagalli, Ida Sirgiovanni, Roberto Giorda, Uberto Pozzoli, Francesco Morandi, Silvana Beri, Giorgia Menozzi, Fabio Mosca, Renato Borgatti, Rosario Montirosso |
| Abstract |
Very preterm (VPT) infants need long-lasting hospitalization in the Neonatal Intensive Care Unit (NICU) during which they are daily exposed to pain-related stress. Alterations of DNA methylation at the promoter region of the SLC6A4 have been associated with early adverse experiences in infants. The main aim of the present work was to investigate the association between level of exposure to pain-related stress during hospitalization and changes in SLC6A4 DNA methylation at NICU discharge in VPT infants. In order to exclude the potential effect of birth status (i.e., preterm vs. full-term birth) on SLC6A4 methylation, we preliminarily assessed SLC6A4 epigenetic differences between VPT and full-term (FT) infants at birth. Fifty-six VPT and thirty-two FT infants participated in the study. The level of exposure to pain-related stress was quantified on the basis of the amount of skin-breaking procedures to which they were exposed. VPT infants were divided in two sub-groups: low-pain exposure (LPE, N = 25) and high-pain exposure (HPE, N = 31). DNA methylation was evaluated at birth for both VPT and FT infants, assessing 20 CpG sites within the SLC6A4 promoter region. The same CpG sites were re-evaluated for variations in DNA methylation at NICU discharge in LPE and HPE VPT infants. No differences in SLC6A4 CpG sites' methylation emerged between FT and VPT infants at birth. Methylation at CpG sites 5 and 6 significantly increased from birth to NICU discharge only for HPE VPT infants. Findings show that preterm birth per se is not associated with epigenetic alterations of the SLC6A4, whereas higher levels of pain-related stress exposure during NICU stay might alter the transcriptional functionality of the serotonin transporter gene. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 25% |
| France | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 50% |
| Members of the public | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | <1% |
| Norway | 1 | <1% |
| Brazil | 1 | <1% |
| United States | 1 | <1% |
| Croatia | 1 | <1% |
| Unknown | 103 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 16% |
| Researcher | 17 | 16% |
| Student > Master | 12 | 11% |
| Student > Bachelor | 12 | 11% |
| Student > Doctoral Student | 9 | 8% |
| Other | 16 | 15% |
| Unknown | 25 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 20% |
| Psychology | 16 | 15% |
| Nursing and Health Professions | 13 | 12% |
| Neuroscience | 10 | 9% |
| Biochemistry, Genetics and Molecular Biology | 9 | 8% |
| Other | 12 | 11% |
| Unknown | 26 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2018.
All research outputs
#2,563,474
of 22,799,071 outputs
Outputs from Frontiers in Behavioral Neuroscience
#445
of 3,165 outputs
Outputs of similar age
#34,548
of 265,400 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#10
of 74 outputs
Altmetric has tracked 22,799,071 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,165 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,400 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.