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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Social Preference Deficits in Juvenile Zebrafish Induced by Early Chronic Exposure to Sodium Valproate
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, October 2016
|
| DOI | 10.3389/fnbeh.2016.00201 |
| Pubmed ID | |
| Authors |
Xiuyun Liu, Yinglan Zhang, Jia Lin, Qiaoxi Xia, Ning Guo, Qiang Li |
| Abstract |
Prenatal exposure to sodium valproate (VPA), a widely used anti-epileptic drug, is related to a series of dysfunctions, such as deficits in language and communication. Clinical and animal studies have indicated that the effects of VPA are related to the concentration and to the exposure window, while the neurobehavioral effects of VPA have received limited research attention. In the current study, to analyze the neurobehavioral effects of VPA, zebrafish at 24 h post-fertilization (hpf) were treated with early chronic exposure to 20 μM VPA for 7 h per day for 6 days or with early acute exposure to 100 μM VPA for 7 h. A battery of behavioral screenings was conducted at 1 month of age to investigate social preference, locomotor activity, anxiety, and behavioral response to light change. A social preference deficit was only observed in animals with chronic VPA exposure. Acute VPA exposure induced a change in the locomotor activity, while chronic VPA exposure did not affect locomotor activity. Neither exposure procedure influenced anxiety or the behavioral response to light change. These results suggested that VPA has the potential to affect some behaviors in zebrafish, such as social behavior and the locomotor activity, and that the effects were closely related to the concentration and the exposure window. Additionally, social preference seemed to be independent from other simple behaviors. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 13% |
| Student > Master | 9 | 13% |
| Student > Bachelor | 9 | 13% |
| Student > Ph. D. Student | 6 | 9% |
| Other | 4 | 6% |
| Other | 14 | 21% |
| Unknown | 17 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 18% |
| Psychology | 8 | 12% |
| Agricultural and Biological Sciences | 8 | 12% |
| Biochemistry, Genetics and Molecular Biology | 6 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
| Other | 12 | 18% |
| Unknown | 18 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 October 2016.
All research outputs
#20,349,664
of 22,896,955 outputs
Outputs from Frontiers in Behavioral Neuroscience
#2,844
of 3,190 outputs
Outputs of similar age
#273,169
of 315,898 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#57
of 61 outputs
Altmetric has tracked 22,896,955 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,190 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.