The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Behavioral Effects of Acute Systemic Low-Dose Clozapine in Wild-Type Rats: Implications for the Use of DREADDs in Behavioral Neuroscience
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, August 2018
|
| DOI | 10.3389/fnbeh.2018.00173 |
| Pubmed ID | |
| Authors |
Ann-Kathrin Ilg, Thomas Enkel, Dusan Bartsch, Florian Bähner |
| Abstract |
Designer receptors exclusively activated by designer drugs (DREADDs) are popular tools used to manipulate the activity of defined groups of neurons. Recent work has shown that DREADD effects in the brain are most likely not mediated by the proposed ligand clozapine-N-oxide (CNO) but its metabolite clozapine (CLOZ). However, it is not known whether low doses of CLOZ required to activate DREADDs already have DREADD-independent effects on behavior as described for higher CLOZ doses used in previous preclinical studies. To close this gap, we compared effects of acute systemic (i.p.) CLOZ treatment vs. vehicle (VEH) in a wide range of behavioral tests in male wild-type rats. We found that CLOZ doses as low as 0.05-0.1 mg/kg significantly affected locomotion, anxiety and cognitive flexibility but had no effect on working memory or social interaction. These results highlight the need for careful controls in future chemogenetic experiments and show that previous results in studies lacking CNO/CLOZ controls may require critical re-evaluation. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 36% |
| United Kingdom | 2 | 9% |
| Thailand | 1 | 5% |
| Japan | 1 | 5% |
| Switzerland | 1 | 5% |
| Mexico | 1 | 5% |
| Canada | 1 | 5% |
| Unknown | 7 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 64% |
| Scientists | 7 | 32% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 117 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 21% |
| Researcher | 19 | 16% |
| Student > Master | 19 | 16% |
| Student > Bachelor | 16 | 14% |
| Student > Doctoral Student | 6 | 5% |
| Other | 9 | 8% |
| Unknown | 24 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 54 | 46% |
| Agricultural and Biological Sciences | 13 | 11% |
| Biochemistry, Genetics and Molecular Biology | 8 | 7% |
| Psychology | 6 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 8 | 7% |
| Unknown | 25 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2018.
All research outputs
#3,320,415
of 24,903,209 outputs
Outputs from Frontiers in Behavioral Neuroscience
#591
of 3,403 outputs
Outputs of similar age
#63,507
of 336,508 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#22
of 94 outputs
Altmetric has tracked 24,903,209 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,403 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,508 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.