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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Asthma Induction During Development and Adult Lung Function, Behavior and Brain Gene Expression
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, August 2018
|
| DOI | 10.3389/fnbeh.2018.00188 |
| Pubmed ID | |
| Authors |
Jasmine I. Caulfield, Michael J. Caruso, Rebecca A. Bourne, Nicole R. Chirichella, Laura C. Klein, Timothy Craig, Robert H. Bonneau, Avery August, Sonia A. Cavigelli |
| Abstract |
In developing youth, allergic asthma is the most common chronic condition, with 9%-10% of youth affected. Asthma onset during childhood and adolescence is further associated with other health issues, particularly psychiatric conditions. To understand causal mechanisms by which developmental asthma may lead to altered behavior, brain and health trajectories, we developed a mouse model of developmental allergic asthma. In the current study, we tested for potential long-term effects of developmental asthma on adult lung function and behavior and brain gene expression associated with emotion and stress regulation. We manipulated airway inflammation (AI) and methacholine (MCH)-induced bronchospasm (resulting in labored breathing, LB) in young male and female BALB/cJ mice and measured adult outcomes 3 months after final asthma manipulations. Results indicated that allergen exposure, used to cause AI, and which ended on post-natal day 56 (P56), led to persistent lung AI, mucus buildup and gene expression related to allergic asthma 3 months after final allergen exposure. In addition, at this same age, early allergen exposure led to altered brain gene expression related to stress regulation (prefrontal corticotropin releasing hormone receptor 1, Crhr1 and hippocampal glucocorticoid receptor, GR) and serotonin function (brainstem serotonin transporter, SERT). On the other hand, LB events during development led to altered anxiety-related behavior. Importantly, sex and pre-asthma fear-related behavior (ultrasonic vocalization, USV rates) modulated these adult outcomes. Asthma that develops during childhood/adolescence may have long-term impacts on emotion and stress regulation mechanisms, and these influences may be moderated by sex and pre-asthma temperament. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 50% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 17% |
| Student > Bachelor | 4 | 9% |
| Student > Postgraduate | 3 | 7% |
| Researcher | 2 | 4% |
| Professor > Associate Professor | 2 | 4% |
| Other | 5 | 11% |
| Unknown | 22 | 48% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 5 | 11% |
| Medicine and Dentistry | 4 | 9% |
| Neuroscience | 3 | 7% |
| Immunology and Microbiology | 3 | 7% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Other | 3 | 7% |
| Unknown | 26 | 57% |
Attention Score in Context
This research output has an Altmetric Attention Score of 136. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2020.
All research outputs
#259,972
of 23,102,082 outputs
Outputs from Frontiers in Behavioral Neuroscience
#47
of 3,215 outputs
Outputs of similar age
#6,103
of 334,790 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#1
of 95 outputs
Altmetric has tracked 23,102,082 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,215 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,790 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.