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A Hypothesis of the Interaction of the Nitrergic and Serotonergic Systems in Aggressive Behavior Induced by Exposure to Lead

Overview of attention for article published in Frontiers in Behavioral Neuroscience, September 2018
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Average Attention Score compared to outputs of the same age and source

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6 X users

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Title
A Hypothesis of the Interaction of the Nitrergic and Serotonergic Systems in Aggressive Behavior Induced by Exposure to Lead
Published in
Frontiers in Behavioral Neuroscience, September 2018
DOI 10.3389/fnbeh.2018.00202
Pubmed ID
Authors

Juan Carlos Martínez-Lazcano, Alfredo López-Quiroz, Rocío Alcantar-Almaraz, Sergio Montes, Alicia Sánchez-Mendoza, Mireya Alcaraz-Zubeldia, Luis Antonio Tristán-López, Beatriz Eugenia Sánchez-Hernández, Adriana Morales-Martínez, Camilo Ríos, Francisca Pérez-Severiano

Abstract

The effects caused by exposure to lead (Pb) are still considered as a relevant health risk despite public policies aimed to restricting the use of this element. The toxicity limit in the blood (10 μg/dL, established by the Center for Disease Control and Prevention) has been insufficient to prevent adverse effects and even lower values have been related to neurobehavioral dysfunctions in children. Currently, there is not a safe limit of exposure to Pb. A large body of evidence points to environmental pollutant exposure as the cause of predisposition to violent behavior, among others. Considering the evidence by our group and others, we propose that Pb exposure induces alterations in the brain vasculature, specifically in nitric oxide synthases (NOS), affecting in turn the serotonergic system and leading to heightened aggressive behavior in the exposed individuals. This review article describes the consequences of Pb exposure on the nitrergic and serotonergic systems as well as its relationship with aggressive behavior. In addition, it summarizes the available therapy to prevent damage in gestation and among infants.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 11%
Researcher 4 9%
Student > Doctoral Student 4 9%
Student > Ph. D. Student 3 7%
Student > Master 3 7%
Other 8 18%
Unknown 17 39%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 4 9%
Agricultural and Biological Sciences 4 9%
Medicine and Dentistry 4 9%
Biochemistry, Genetics and Molecular Biology 3 7%
Neuroscience 2 5%
Other 7 16%
Unknown 20 45%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2023.
All research outputs
#13,277,233
of 23,394,089 outputs
Outputs from Frontiers in Behavioral Neuroscience
#1,471
of 3,251 outputs
Outputs of similar age
#161,524
of 336,531 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#48
of 93 outputs
Altmetric has tracked 23,394,089 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,251 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.6. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,531 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.