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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The reciprocal regulation of stress hormones and GABAA receptors
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, January 2012
|
| DOI | 10.3389/fncel.2012.00004 |
| Pubmed ID | |
| Authors |
Istvan Mody, Jamie Maguire |
| Abstract |
Stress-derived steroid hormones regulate the expression and function of GABA(A) receptors (GABA(A)Rs). Changes in GABA(A)R subunit expression have been demonstrated under conditions of altered steroid hormone levels, such as stress, as well as following exogenous steroid hormone administration. In addition to the effects of stress-derived steroid hormones on GABA(A)R subunit expression, stress hormones can also be metabolized to neuroactive derivatives which can alter the function of GABA(A)Rs. Neurosteroids allosterically modulate GABA(A)Rs at concentrations comparable to those during stress. In addition to the actions of stress-derived steroid hormones on GABA(A)Rs, GABA(A)Rs reciprocally regulate the production of stress hormones. The stress response is mediated by the hypothalamic-pituitary-adrenal (HPA) axis, the activity of which is governed by corticotropin releasing hormone (CRH) neurons. The activity of CRH neurons is largely controlled by robust GABAergic inhibition. Recently, it has been demonstrated that CRH neurons are regulated by neurosteroid-sensitive, GABA(A)R δ subunit-containing receptors representing a novel feedback mechanism onto the HPA axis. Further, it has been demonstrated that neurosteroidogenesis and neurosteroid actions on GABA(A)R δ subunit-containing receptors on CRH neurons are necessary to mount the physiological response to stress. Here we review the literature describing the effects of steroid hormones on GABA(A)Rs as well as the importance of GABA(A)Rs in regulating the production of steroid hormones. This review incorporates what we currently know about changes in GABA(A)Rs following stress and the role in HPA axis regulation. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Colombia | 1 | <1% |
| Chile | 1 | <1% |
| Austria | 1 | <1% |
| Australia | 1 | <1% |
| Germany | 1 | <1% |
| Sweden | 1 | <1% |
| Brazil | 1 | <1% |
| Israel | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 110 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 18% |
| Researcher | 21 | 17% |
| Student > Bachelor | 16 | 13% |
| Student > Doctoral Student | 14 | 12% |
| Student > Master | 9 | 7% |
| Other | 24 | 20% |
| Unknown | 15 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 26% |
| Neuroscience | 29 | 24% |
| Medicine and Dentistry | 19 | 16% |
| Psychology | 5 | 4% |
| Biochemistry, Genetics and Molecular Biology | 4 | 3% |
| Other | 14 | 12% |
| Unknown | 18 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2012.
All research outputs
#21,635,684
of 26,559,802 outputs
Outputs from Frontiers in Cellular Neuroscience
#3,725
of 4,824 outputs
Outputs of similar age
#209,522
of 254,882 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#31
of 42 outputs
Altmetric has tracked 26,559,802 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,824 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.