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Mendeley readers
Attention Score in Context
| Title |
Synaptic regulation of the hypothalamic–pituitary–adrenal axis and its modulation by glucocorticoids and stress
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, January 2012
|
| DOI | 10.3389/fncel.2012.00024 |
| Pubmed ID | |
| Authors |
Benjamin H. Levy, Jeffrey G. Tasker |
| Abstract |
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been implicated in a range of affective and stress-related disorders. The regulatory systems that control HPA activity are subject to modulation by environmental influences, and stressful life events or circumstances can promote subsequent HPA dysregulation. The brain is a major regulator of the HPA axis, and stress-induced plasticity of the neural circuitry involved in HPA regulation might constitute an etiological link between stress and the development of HPA dysregulation. This review focuses on the synaptic regulation of neuroendocrine corticotropin-releasing hormone (CRH) neurons of the hypothalamic paraventricular nucleus, which are the cells through which the brain predominantly exerts its influence on the HPA axis. CRH neuronal activity is largely orchestrated by three neurotransmitters: GABA, glutamate, and norepinephrine. We discuss our current understanding of the neural circuitry through which these neurotransmitters regulate CRH cell activity, as well as the plastic changes in this circuitry induced by acute and chronic stress and the resultant changes in HPA function. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 3% |
| Canada | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 222 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 51 | 22% |
| Student > Bachelor | 39 | 17% |
| Researcher | 32 | 14% |
| Student > Master | 19 | 8% |
| Student > Doctoral Student | 17 | 7% |
| Other | 39 | 17% |
| Unknown | 33 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 68 | 30% |
| Neuroscience | 38 | 17% |
| Medicine and Dentistry | 30 | 13% |
| Biochemistry, Genetics and Molecular Biology | 12 | 5% |
| Psychology | 8 | 3% |
| Other | 23 | 10% |
| Unknown | 51 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2013.
All research outputs
#15,271,909
of 22,710,079 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,647
of 4,210 outputs
Outputs of similar age
#163,253
of 244,153 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#16
of 42 outputs
Altmetric has tracked 22,710,079 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,210 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,153 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.