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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Wnts in action: from synapse formation to synaptic maintenance
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, January 2013
|
| DOI | 10.3389/fncel.2013.00162 |
| Pubmed ID | |
| Authors |
Ellen M. Dickins, Patricia C. Salinas |
| Abstract |
A proper balance between synapse assembly and disassembly is crucial for the formation of functional neuronal circuits and synaptic plasticity in the adult brain. During development, synaptogenesis generates a vast excess of synapses, which are subsequently eliminated. Importantly, aberrant synaptic disassembly during development underpins many neurological disorders. Wnt secreted proteins are robust synaptogenic factors that regulate synapse assembly and function in the developing and mature brain. Recent studies show that Wnt blockade with the antagonist Dickkopf-1 (Dkk1) induces the rapid disassembly of synapses in mature neurons. Importantly, Dkk1 mediates synaptic loss induced by Amyloid-ß, a key pathogenic molecule in Alzheimer's disease (AD). These findings provide new insights into the potential contribution of dysfunctional Wnt signaling to synaptic loss observed in neurodegenerative diseases. In this review, we discuss the role of Wnt signaling in vertebrate synaptic assembly, function and maintenance, and consider how dysfunction of Wnt signaling could contribute to synaptic disassembly in neurodegenerative diseases such as AD. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 168 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Chile | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 164 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 23% |
| Researcher | 30 | 18% |
| Student > Bachelor | 27 | 16% |
| Student > Master | 18 | 11% |
| Student > Doctoral Student | 11 | 7% |
| Other | 14 | 8% |
| Unknown | 29 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 60 | 36% |
| Neuroscience | 38 | 23% |
| Biochemistry, Genetics and Molecular Biology | 18 | 11% |
| Medicine and Dentistry | 6 | 4% |
| Chemistry | 3 | 2% |
| Other | 10 | 6% |
| Unknown | 33 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2013.
All research outputs
#17,702,587
of 22,731,677 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,912
of 4,215 outputs
Outputs of similar age
#210,226
of 280,769 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#124
of 203 outputs
Altmetric has tracked 22,731,677 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,215 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,769 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 203 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.