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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The role of the blood–brain barrier in the development and treatment of migraine and other pain disorders
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, October 2014
|
| DOI | 10.3389/fncel.2014.00302 |
| Pubmed ID | |
| Authors |
Marcos F. DosSantos, Rosenilde C. Holanda-Afonso, Rodrigo L. Lima, Alexandre F. DaSilva, Vivaldo Moura-Neto |
| Abstract |
The function of the blood-brain barrier (BBB) related to chronic pain has been explored for its classical role in regulating the transcellular and paracellular transport, thus controlling the flow of drugs that act at the central nervous system, such as opioid analgesics (e.g., morphine) and non-steroidal anti-inflammatory drugs. Nonetheless, recent studies have raised the possibility that changes in the BBB permeability might be associated with chronic pain. For instance, changes in the relative amounts of occludin isoforms, resulting in significant increases in the BBB permeability, have been demonstrated after inflammatory hyperalgesia. Furthermore, inflammatory pain produces structural changes in the P-glycoprotein, the major efflux transporter at the BBB. One possible explanation for these findings is the action of substances typically released at the site of peripheral injuries that could lead to changes in the brain endothelial permeability, including substance P, calcitonin gene-related peptide, and interleukin-1 beta. Interestingly, inflammatory pain also results in microglial activation, which potentiates the BBB damage. In fact, astrocytes and microglia play a critical role in maintaining the BBB integrity and the activation of those cells is considered a key mechanism underlying chronic pain. Despite the recent advances in the understanding of BBB function in pain development as well as its interference in the efficacy of analgesic drugs, there remain unknowns regarding the molecular mechanisms involved in this process. In this review, we explore the connection between the BBB as well as the blood-spinal cord barrier and blood-nerve barrier, and pain, focusing on cellular and molecular mechanisms of BBB permeabilization induced by inflammatory or neuropathic pain and migraine. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 168 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Denmark | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 165 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 17% |
| Researcher | 25 | 15% |
| Student > Bachelor | 23 | 14% |
| Student > Master | 19 | 11% |
| Other | 14 | 8% |
| Other | 24 | 14% |
| Unknown | 34 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 26% |
| Agricultural and Biological Sciences | 17 | 10% |
| Neuroscience | 16 | 10% |
| Biochemistry, Genetics and Molecular Biology | 14 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Other | 24 | 14% |
| Unknown | 47 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2014.
All research outputs
#18,381,794
of 22,768,097 outputs
Outputs from Frontiers in Cellular Neuroscience
#3,242
of 4,229 outputs
Outputs of similar age
#182,214
of 255,124 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#49
of 89 outputs
Altmetric has tracked 22,768,097 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,229 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,124 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.