The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Shedding of APP limits its synaptogenic activity and cell adhesion properties
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, December 2014
|
| DOI | 10.3389/fncel.2014.00410 |
| Pubmed ID | |
| Authors |
Ronny Stahl, Sandra Schilling, Peter Soba, Carsten Rupp, Tobias Hartmann, Katja Wagner, Gunter Merdes, Simone Eggert, Stefan Kins |
| Abstract |
The amyloid precursor protein (APP) plays a central role in Alzheimer's disease (AD) and has essential synapse promoting functions. Synaptogenic activity as well as cell adhesion properties of APP presumably depend on trans-cellular dimerization via its extracellular domain. Since neuronal APP is extensively processed by secretases, it raises the question if APP shedding affects its cell adhesion and synaptogenic properties. We show that inhibition of APP shedding using cleavage deficient forms of APP or a dominant negative α-secretase strongly enhanced its cell adhesion and synaptogenic activity suggesting that synapse promoting function of APP is tightly regulated by α-secretase mediated processing, similar to other trans-cellular synaptic adhesion molecules. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Unknown | 62 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 27% |
| Student > Bachelor | 10 | 16% |
| Student > Master | 9 | 14% |
| Researcher | 9 | 14% |
| Student > Doctoral Student | 3 | 5% |
| Other | 4 | 6% |
| Unknown | 11 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 33% |
| Neuroscience | 14 | 22% |
| Biochemistry, Genetics and Molecular Biology | 10 | 16% |
| Veterinary Science and Veterinary Medicine | 1 | 2% |
| Physics and Astronomy | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 13 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2014.
All research outputs
#15,312,760
of 22,774,233 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,659
of 4,230 outputs
Outputs of similar age
#213,678
of 360,902 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#43
of 84 outputs
Altmetric has tracked 22,774,233 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,230 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,902 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.