Title |
Thrombin regulation of synaptic transmission and plasticity: implications for health and disease
|
---|---|
Published in |
Frontiers in Cellular Neuroscience, April 2015
|
DOI | 10.3389/fncel.2015.00151 |
Pubmed ID | |
Authors |
Marina Ben Shimon, Maximilian Lenz, Benno Ikenberg, Denise Becker, Efrat Shavit Stein, Joab Chapman, David Tanne, Chaim G. Pick, Ilan Blatt, Miri Neufeld, Andreas Vlachos, Nicola Maggio |
Abstract |
Thrombin, a serine protease involved in the blood coagulation cascade has been shown to affect neural function following blood-brain barrier breakdown. However, several lines of evidence exist that thrombin is also expressed in the brain under physiological conditions, suggesting an involvement of thrombin in the regulation of normal brain functions. Here, we review ours' as well as others' recent work on the role of thrombin in synaptic transmission and plasticity through direct or indirect activation of Protease-Activated Receptor-1 (PAR1). These studies propose a novel role of thrombin in synaptic plasticity, both in physiology as well as in neurological diseases associated with increased brain thrombin/PAR1 levels. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Israel | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
India | 1 | 1% |
Germany | 1 | 1% |
Unknown | 71 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 18% |
Student > Master | 11 | 15% |
Student > Ph. D. Student | 10 | 14% |
Student > Bachelor | 5 | 7% |
Other | 5 | 7% |
Other | 10 | 14% |
Unknown | 20 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 21 | 28% |
Medicine and Dentistry | 12 | 16% |
Agricultural and Biological Sciences | 9 | 12% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Other | 5 | 7% |
Unknown | 19 | 26% |