Title |
The role of the GABA system in amphetamine-type stimulant use disorders
|
---|---|
Published in |
Frontiers in Cellular Neuroscience, May 2015
|
DOI | 10.3389/fncel.2015.00162 |
Pubmed ID | |
Authors |
Dongliang Jiao, Yao liu, Xiaohong Li, Jinggen liu, Min Zhao |
Abstract |
Abuse of amphetamine-type stimulants (ATS) has become a global public health problem. ATS causes severe neurotoxicity, which could lead to addiction and could induce psychotic disorders or cognitive dysfunctions. However, until now, there has been a lack of effective medicines for treating ATS-related problems. Findings from recent studies indicate that in addition to the traditional dopamine-ergic system, the GABA (gamma-aminobutyric acid)-ergic system plays an important role in ATS abuse. However, the exact mechanisms of the GABA-ergic system in amphetamine-type stimulant use disorders are not fully understood. This review discusses the role of the GABA-ergic system in ATS use disorders, including ATS induced psychotic disorders and cognitive dysfunctions. We conclude that the GABA-ergic system are importantly involved in the development of ATS use disorders through multiple pathways, and that therapies or medicines that target specific members of the GABA-ergic system may be novel effective interventions for the treatment of ATS use disorders. |
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