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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Hormones and immunity in cancer: are thyroid hormones endocrine players in the microglia/glioma cross-talk?
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, June 2015
|
| DOI | 10.3389/fncel.2015.00236 |
| Pubmed ID | |
| Authors |
Cristiana Perrotta, Clara De Palma, Emilio Clementi, Davide Cervia |
| Abstract |
Accumulating evidence indicates that the endocrine and immune systems engage in complex cross-talks in which a prominent role is played by thyroid hormones (THs). The increase of resident vs. monocyte recruited macrophages was shown to be an important effector of the TH 3,3',5'-Triiodo-L-thyronine (T3)-induced protection against inflammation and a key role of T3 in inhibiting the differentiation of peripheral monocytes into macrophages was observed. Herein, we report on the role of T3 as a modulator of microglia, the specialized macrophages of the central nervous system (CNS). Mounting evidence supports a role of microglia and macrophages in the growth and invasion of malignant glioma. In this respect, we unveil the putative involvement of T3 in the microglia/glioma cell communication. Since THs are known to cross the blood-brain barrier, we suggest that T3 not only exerts a direct modulation of brain cancer cell itself but also indirectly promotes glioma growth through a modulation of microglia. Our observations expand available information on the role of TH system in glioma and its microenvironment and highlight the endocrine modulation of microglia as an important target for future therapeutic development of glioma treatments. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 25% |
| United States | 1 | 25% |
| Switzerland | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 1 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 23% |
| Student > Master | 5 | 16% |
| Researcher | 5 | 16% |
| Student > Bachelor | 3 | 10% |
| Professor | 2 | 6% |
| Other | 3 | 10% |
| Unknown | 6 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 7 | 23% |
| Biochemistry, Genetics and Molecular Biology | 4 | 13% |
| Medicine and Dentistry | 4 | 13% |
| Agricultural and Biological Sciences | 3 | 10% |
| Arts and Humanities | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 9 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2016.
All research outputs
#14,508,759
of 25,233,554 outputs
Outputs from Frontiers in Cellular Neuroscience
#1,833
of 4,676 outputs
Outputs of similar age
#123,663
of 270,257 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#49
of 126 outputs
Altmetric has tracked 25,233,554 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,676 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,257 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.