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X Demographics
Mendeley readers
Attention Score in Context
| Title |
In vivo characterization of microglial engulfment of dying neurons in the zebrafish spinal cord
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, August 2015
|
| DOI | 10.3389/fncel.2015.00321 |
| Pubmed ID | |
| Authors |
Marco Morsch, Rowan Radford, Albert Lee, Emily K. Don, Andrew P. Badrock, Thomas E. Hall, Nicholas J. Cole, Roger Chung |
| Abstract |
Microglia are specialized phagocytes in the vertebrate central nervous system (CNS). As the resident immune cells of the CNS they play an important role in the removal of dying neurons during both development and in several neuronal pathologies. Microglia have been shown to prevent the diffusion of damaging degradation products of dying neurons by engulfment and ingestion. Here we describe a live imaging approach that uses UV laser ablation to selectively stress and kill spinal neurons and visualize the clearance of neuronal remnants by microglia in the zebrafish spinal cord. In vivo imaging confirmed the motile nature of microglia within the uninjured spinal cord. However, selective neuronal ablation triggered rapid activation of microglia, leading to phagocytic uptake of neuronal debris by microglia within 20-30 min. This process of microglial engulfment is highly dynamic, involving the extension of processes toward the lesion site and consequently the ingestion of the dying neuron. 3D rendering analysis of time-lapse recordings revealed the formation of phagosome-like structures in the activated microglia located at the site of neuronal ablation. This real-time representation of microglial phagocytosis in the living zebrafish spinal cord provides novel opportunities to study the mechanisms of microglia-mediated neuronal clearance. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 142 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 140 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 26% |
| Researcher | 19 | 13% |
| Student > Bachelor | 16 | 11% |
| Student > Master | 14 | 10% |
| Professor | 9 | 6% |
| Other | 24 | 17% |
| Unknown | 23 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 36 | 25% |
| Agricultural and Biological Sciences | 31 | 22% |
| Biochemistry, Genetics and Molecular Biology | 29 | 20% |
| Medicine and Dentistry | 6 | 4% |
| Computer Science | 2 | 1% |
| Other | 8 | 6% |
| Unknown | 30 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2015.
All research outputs
#14,173,668
of 22,826,360 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,163
of 4,246 outputs
Outputs of similar age
#137,093
of 266,721 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#63
of 140 outputs
Altmetric has tracked 22,826,360 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,246 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,721 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 140 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.