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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Alterations in Mitochondrial Quality Control in Alzheimer’s Disease
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, February 2016
|
| DOI | 10.3389/fncel.2016.00024 |
| Pubmed ID | |
| Authors |
Qian Cai, Prasad Tammineni |
| Abstract |
Mitochondrial dysfunction is one of the earliest and most prominent features in the brains of Alzheimer's disease (AD) patients. Recent studies suggest that mitochondrial dysfunction plays a pivotal role in the pathogenesis of AD. Neurons are metabolically active cells, causing them to be particularly dependent on mitochondrial function for survival and maintenance. As highly dynamic organelles, mitochondria are characterized by a balance of fusion and fission, transport, and mitophagy, all of which are essential for maintaining mitochondrial integrity and function. Mitochondrial dynamics and mitophagy can therefore be identified as key pathways in mitochondrial quality control. Tremendous progress has been made in studying changes in these key aspects of mitochondrial biology in the vulnerable neurons of AD brains and mouse models, and the potential underlying mechanisms of such changes. This review highlights recent findings on alterations in the mitochondrial dynamics and mitophagy in AD and discusses how these abnormalities impact mitochondrial quality control and thus contribute to mitochondrial dysfunction in AD. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 219 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 217 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 17% |
| Student > Bachelor | 35 | 16% |
| Student > Master | 31 | 14% |
| Researcher | 29 | 13% |
| Student > Doctoral Student | 11 | 5% |
| Other | 20 | 9% |
| Unknown | 55 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 50 | 23% |
| Agricultural and Biological Sciences | 48 | 22% |
| Neuroscience | 20 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 6% |
| Medicine and Dentistry | 12 | 5% |
| Other | 13 | 6% |
| Unknown | 62 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2016.
All research outputs
#2,778,183
of 22,844,985 outputs
Outputs from Frontiers in Cellular Neuroscience
#517
of 4,252 outputs
Outputs of similar age
#51,974
of 400,364 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#11
of 96 outputs
Altmetric has tracked 22,844,985 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,252 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 400,364 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.