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Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke

Overview of attention for article published in Frontiers in Cellular Neuroscience, March 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

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8 X users
patent
2 patents
wikipedia
1 Wikipedia page

Citations

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363 Dimensions

Readers on

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237 Mendeley
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Title
Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke
Published in
Frontiers in Cellular Neuroscience, March 2016
DOI 10.3389/fncel.2016.00056
Pubmed ID
Authors

Renée J. Turner, Frank R. Sharp

Abstract

Numerous studies have documented increases in matrix metalloproteinases (MMPs), specifically MMP-9 levels following stroke, with such perturbations associated with disruption of the blood brain barrier (BBB), increased risk of hemorrhagic complications, and worsened outcome. Despite this, controversy remains as to which cells release MMP-9 at the normal and pathological BBB, with even less clarity in the context of stroke. This may be further complicated by the influence of tissue plasminogen activator (tPA) treatment. The aim of the present review is to examine the relationship between neutrophils, MMP-9 and tPA following ischemic stroke to elucidate which cells are responsible for the increases in MMP-9 and resultant barrier changes and hemorrhage observed following stroke.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 237 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hong Kong 1 <1%
Unknown 236 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 50 21%
Student > Bachelor 35 15%
Student > Master 25 11%
Researcher 18 8%
Other 12 5%
Other 36 15%
Unknown 61 26%
Readers by discipline Count As %
Neuroscience 42 18%
Medicine and Dentistry 41 17%
Biochemistry, Genetics and Molecular Biology 27 11%
Agricultural and Biological Sciences 21 9%
Pharmacology, Toxicology and Pharmaceutical Science 14 6%
Other 22 9%
Unknown 70 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2024.
All research outputs
#3,269,008
of 25,393,455 outputs
Outputs from Frontiers in Cellular Neuroscience
#626
of 4,693 outputs
Outputs of similar age
#49,602
of 313,762 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#13
of 104 outputs
Altmetric has tracked 25,393,455 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,693 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,762 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.