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Mechanisms of Polarized Organelle Distribution in Neurons

Overview of attention for article published in Frontiers in Cellular Neuroscience, March 2016
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4 X users

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117 Mendeley
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Title
Mechanisms of Polarized Organelle Distribution in Neurons
Published in
Frontiers in Cellular Neuroscience, March 2016
DOI 10.3389/fncel.2016.00088
Pubmed ID
Authors

Dylan J. Britt, Ginny G. Farías, Carlos M. Guardia, Juan S. Bonifacino

Abstract

Neurons are highly polarized cells exhibiting axonal and somatodendritic domains with distinct complements of cytoplasmic organelles. Although some organelles are widely distributed throughout the neuronal cytoplasm, others are segregated to either the axonal or somatodendritic domains. Recent findings show that organelle segregation is largely established at a pre-axonal exclusion zone (PAEZ) within the axon hillock. Polarized sorting of cytoplasmic organelles at the PAEZ is proposed to depend mainly on their selective association with different microtubule motors and, in turn, with distinct microtubule arrays. Somatodendritic organelles that escape sorting at the PAEZ can be subsequently retrieved at the axon initial segment (AIS) by a microtubule- and/or actin-based mechanism. Dynamic sorting along the PAEZ-AIS continuum can thus explain the polarized distribution of cytoplasmic organelles between the axonal and somatodendritic domains.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 116 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 21%
Researcher 20 17%
Student > Bachelor 15 13%
Student > Master 13 11%
Student > Doctoral Student 5 4%
Other 14 12%
Unknown 25 21%
Readers by discipline Count As %
Neuroscience 33 28%
Agricultural and Biological Sciences 28 24%
Biochemistry, Genetics and Molecular Biology 21 18%
Medicine and Dentistry 4 3%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 5 4%
Unknown 24 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2016.
All research outputs
#14,254,293
of 22,858,915 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,206
of 4,254 outputs
Outputs of similar age
#160,468
of 301,000 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#47
of 93 outputs
Altmetric has tracked 22,858,915 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,254 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 301,000 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.