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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Extracellular Vesicles in Physiology, Pathology, and Therapy of the Immune and Central Nervous System, with Focus on Extracellular Vesicles Derived from Mesenchymal Stem Cells as Therapeutic Tools
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, May 2016
|
| DOI | 10.3389/fncel.2016.00109 |
| Pubmed ID | |
| Authors |
Sylwia Koniusz, Anna Andrzejewska, Maurizio Muraca, Amit K. Srivastava, Miroslaw Janowski, Barbara Lukomska |
| Abstract |
Extracellular vesicles (EVs) are membrane-surrounded structures released by most cell types. They are characterized by a specific set of proteins, lipids and nucleic acids. EVs have been recognized as potent vehicles of intercellular communication to transmit biological signals between cells. In addition, pathophysiological roles of EVs in conditions like cancer, infectious diseases and neurodegenerative disorders are well established. In recent years focus has been shifted on therapeutic use of stem cell derived-EVs. Use of stem cell derived-EVs present distinct advantage over the whole stem cells as EVs do not replicate and after intravenous administration, they are less likely to trap inside the lungs. From the therapeutic perspective, the most promising cellular sources of EVs are mesenchymal stem cells (MSCs), which are easy to obtain and maintain. Therapeutic activity of MSCs has been shown in numerous animal models and the beneficial paracrine effect of MSCs may be mediated by EVs. The various components of MSC derived-EVs such as proteins, lipids, and RNA might play a specific therapeutic role. In this review, we characterize the role of EVs in immune and central nervous system (CNS); present evidences for defective signaling of these vesicles in neurodegeneration and therapeutic role of EVs in CNS. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 235 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Portugal | 1 | <1% |
| Denmark | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 229 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 18% |
| Student > Bachelor | 34 | 14% |
| Researcher | 31 | 13% |
| Student > Master | 23 | 10% |
| Student > Doctoral Student | 18 | 8% |
| Other | 24 | 10% |
| Unknown | 63 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 60 | 26% |
| Medicine and Dentistry | 29 | 12% |
| Agricultural and Biological Sciences | 20 | 9% |
| Neuroscience | 18 | 8% |
| Engineering | 8 | 3% |
| Other | 29 | 12% |
| Unknown | 71 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2024.
All research outputs
#2,082,859
of 26,316,370 outputs
Outputs from Frontiers in Cellular Neuroscience
#260
of 4,788 outputs
Outputs of similar age
#32,210
of 314,239 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#6
of 88 outputs
Altmetric has tracked 26,316,370 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,788 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,239 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.