Title |
The Revolution in Migraine Genetics: From Aching Channels Disorders to a Next-Generation Medicine
|
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Published in |
Frontiers in Cellular Neuroscience, June 2016
|
DOI | 10.3389/fncel.2016.00156 |
Pubmed ID | |
Authors |
Simona Pellacani, Federico Sicca, Cherubino Di Lorenzo, Gaetano S. Grieco, Giulia Valvo, Cristina Cereda, Anna Rubegni, Filippo M. Santorelli |
Abstract |
Channelopathies are a heterogeneous group of neurological disorders resulting from dysfunction of ion channels located in cell membranes and organelles. The clinical scenario is broad and symptoms such as generalized epilepsy (with or without fever), migraine (with or without aura), episodic ataxia and periodic muscle paralysis are some of the best known consequences of gain- or loss-of-function mutations in ion channels. We review the main clinical effects of ion channel mutations associated with a significant impact on migraine headache. Given the increasing and evolving use of genetic analysis in migraine research-greater emphasis is now placed on genetic markers of dysfunctional biological systems-we also show how novel information in rare monogenic forms of migraine might help to clarify the disease mechanisms in the general population of migraineurs. Next-generation sequencing (NGS) and more accurate and precise phenotyping strategies are expected to further increase understanding of migraine pathophysiology and genetics. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 20% |
Australia | 1 | 10% |
Chile | 1 | 10% |
Switzerland | 1 | 10% |
Unknown | 5 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 9 | 90% |
Scientists | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 2% |
Unknown | 61 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 17 | 27% |
Student > Master | 8 | 13% |
Student > Bachelor | 7 | 11% |
Student > Ph. D. Student | 5 | 8% |
Student > Doctoral Student | 4 | 6% |
Other | 12 | 19% |
Unknown | 9 | 15% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 16 | 26% |
Neuroscience | 11 | 18% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Agricultural and Biological Sciences | 4 | 6% |
Nursing and Health Professions | 3 | 5% |
Other | 7 | 11% |
Unknown | 17 | 27% |