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Dynamic Control of Neurotransmitter Release by Presynaptic Potential

Overview of attention for article published in Frontiers in Cellular Neuroscience, December 2016
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Title
Dynamic Control of Neurotransmitter Release by Presynaptic Potential
Published in
Frontiers in Cellular Neuroscience, December 2016
DOI 10.3389/fncel.2016.00278
Pubmed ID
Authors

Mickael Zbili, Sylvain Rama, Dominique Debanne

Abstract

Action potentials (APs) in the mammalian brain are thought to represent the smallest unit of information transmitted by neurons to their postsynaptic targets. According to this view, neuronal signaling is all-or-none or digital. Increasing evidence suggests, however, that subthreshold changes in presynaptic membrane potential before triggering the spike also determines spike-evoked release of neurotransmitter. We discuss here how analog changes in presynaptic voltage may regulate spike-evoked release of neurotransmitter through the modulation of biophysical state of voltage-gated potassium, calcium and sodium channels in the presynaptic compartment. The contribution of this regulation has been greatly underestimated and we discuss the impact for information processing in neuronal circuits.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Germany 1 2%
Unknown 58 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 22%
Student > Ph. D. Student 10 17%
Student > Doctoral Student 4 7%
Student > Bachelor 4 7%
Student > Master 4 7%
Other 9 15%
Unknown 16 27%
Readers by discipline Count As %
Neuroscience 20 33%
Agricultural and Biological Sciences 11 18%
Engineering 3 5%
Medicine and Dentistry 3 5%
Computer Science 2 3%
Other 5 8%
Unknown 16 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2016.
All research outputs
#17,837,681
of 22,914,829 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,945
of 4,257 outputs
Outputs of similar age
#287,846
of 415,999 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#44
of 70 outputs
Altmetric has tracked 22,914,829 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,257 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 415,999 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.