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Bcl11b—A Critical Neurodevelopmental Transcription Factor—Roles in Health and Disease

Overview of attention for article published in Frontiers in Cellular Neuroscience, March 2017
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Title
Bcl11b—A Critical Neurodevelopmental Transcription Factor—Roles in Health and Disease
Published in
Frontiers in Cellular Neuroscience, March 2017
DOI 10.3389/fncel.2017.00089
Pubmed ID
Authors

Matthew J. Lennon, Simon P. Jones, Michael D. Lovelace, Gilles J. Guillemin, Bruce J. Brew

Abstract

B cell leukemia 11b (Bcl11b) is a zinc finger protein transcription factor with a multiplicity of functions. It works as both a genetic suppressor and activator, acting directly, attaching to promoter regions, as well as indirectly, attaching to promoter-bound transcription factors. Bcl11b is a fundamental transcription factor in fetal development, with important roles for the differentiation and development of various neuronal subtypes in the central nervous system (CNS). It has been used as a specific marker of layer V subcerebral projection neurons as well as striatal interneurons. Bcl11b also has critical developmental functions in the immune, integumentary and cardiac systems, to the extent that Bcl11b knockout mice are incompatible with extra-uterine life. Bcl11b has been implicated in a number of disease states including Huntington's disease, Alzheimer's disease, HIV and T-Cell malignancy, amongst others. Bcl11b is a fascinating protein whose critical roles in the CNS and other parts of the body are yet to be fully explicated. This review summarizes the current literature on Bcl11b and its functions in development, health, and disease as well as future directions for research.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 82 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 20%
Student > Master 9 11%
Student > Bachelor 8 10%
Researcher 7 8%
Student > Doctoral Student 6 7%
Other 10 12%
Unknown 26 31%
Readers by discipline Count As %
Neuroscience 16 19%
Biochemistry, Genetics and Molecular Biology 16 19%
Medicine and Dentistry 7 8%
Agricultural and Biological Sciences 6 7%
Immunology and Microbiology 5 6%
Other 6 7%
Unknown 27 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2017.
All research outputs
#20,412,387
of 22,962,258 outputs
Outputs from Frontiers in Cellular Neuroscience
#3,587
of 4,259 outputs
Outputs of similar age
#269,165
of 308,778 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#89
of 110 outputs
Altmetric has tracked 22,962,258 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,259 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 308,778 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.