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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Divergent Roles of Central Serotonin in Adult Hippocampal Neurogenesis
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, June 2017
|
| DOI | 10.3389/fncel.2017.00185 |
| Pubmed ID | |
| Authors |
Ning-Ning Song, Ying Huang, Xin Yu, Bing Lang, Yu-Qiang Ding, Lei Zhang |
| Abstract |
The central serotonin (5-HT) system is the main target of selective serotonin reuptake inhibitors (SSRIs), the first-line antidepressants widely used in current general practice. One of the prominent features of chronic SSRI treatment in rodents is the enhanced adult neurogenesis in the hippocampus, which has been proposed to contribute to antidepressant effects. Therefore, tremendous effort has been made to decipher how central 5-HT regulates adult hippocampal neurogenesis. In this paper, we review how changes in the central serotonergic system alter adult hippocampal neurogenesis. We focus on data obtained from three categories of genetically engineered mouse models: (1) mice with altered central 5-HT levels from embryonic stages, (2) mice with deletion of 5-HT receptors from embryonic stages, and (3) mice with altered central 5-HT system exclusively in adulthood. These recent findings provide unique insights to interpret the multifaceted roles of central 5-HT on adult hippocampal neurogenesis and its associated effects on depression. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 25% |
| Switzerland | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 66 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 20% |
| Student > Master | 8 | 12% |
| Student > Postgraduate | 7 | 11% |
| Researcher | 6 | 9% |
| Student > Bachelor | 5 | 8% |
| Other | 12 | 18% |
| Unknown | 15 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 22 | 33% |
| Agricultural and Biological Sciences | 9 | 14% |
| Medicine and Dentistry | 5 | 8% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Psychology | 2 | 3% |
| Other | 5 | 8% |
| Unknown | 21 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2017.
All research outputs
#14,355,715
of 22,988,380 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,212
of 4,263 outputs
Outputs of similar age
#175,719
of 314,540 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#58
of 99 outputs
Altmetric has tracked 22,988,380 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,263 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,540 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.