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Journey to the Center of the Fetal Brain: Environmental Exposures and Autophagy

Overview of attention for article published in Frontiers in Cellular Neuroscience, May 2018
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Title
Journey to the Center of the Fetal Brain: Environmental Exposures and Autophagy
Published in
Frontiers in Cellular Neuroscience, May 2018
DOI 10.3389/fncel.2018.00118
Pubmed ID
Authors

Jun Lei, Pilar Calvo, Richard Vigh, Irina Burd

Abstract

Fetal brain development is known to be affected by adverse environmental exposures during pregnancy, including infection, inflammation, hypoxia, alcohol, starvation, and toxins. These exposures are thought to alter autophagy activity in the fetal brain, leading to adverse perinatal outcomes, such as cognitive and sensorimotor deficits. This review introduces the physiologic autophagy pathways in the fetal brain. Next, methods to detect and monitor fetal brain autophagy activity are outlined. An additional discussion explores possible mechanisms by which environmental exposures during pregnancy alter fetal brain autophagy activity. In the final section, a correlation of fetal autophagy activity with the observed postnatal phenotype is attempted. Our main purpose is to provide the current understanding or a lack thereof mechanisms on autophagy, underlying the fetal brain injury exposed to environmental insults.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 25%
Student > Master 4 14%
Student > Ph. D. Student 4 14%
Student > Postgraduate 2 7%
Student > Doctoral Student 2 7%
Other 3 11%
Unknown 6 21%
Readers by discipline Count As %
Medicine and Dentistry 4 14%
Biochemistry, Genetics and Molecular Biology 3 11%
Neuroscience 3 11%
Veterinary Science and Veterinary Medicine 2 7%
Agricultural and Biological Sciences 2 7%
Other 8 29%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2018.
All research outputs
#15,508,366
of 23,047,237 outputs
Outputs from Frontiers in Cellular Neuroscience
#2,689
of 4,267 outputs
Outputs of similar age
#208,063
of 326,458 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#65
of 96 outputs
Altmetric has tracked 23,047,237 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,267 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,458 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.