Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing

Chen Chen, Francisco C. Rodriguez, Heather L. Read, Monty A. Escabí

How do local circuits in the inferior colliculus (IC) process and transform spectral and temporal sound information? Using a four-tetrode array we examined the functional properties of the IC and metrics of its micro circuitry by recording neural activity from neighboring single neurons in the cat. Spectral and temporal response preferences were compared for neurons found on the same and adjacent tetrodes (ATs), as well as across distant recording sites. We found that neighboring neurons had similar preferences while neurons recorded across distant sites were less similar. Best frequency (BF) was the most correlated parameter between neighboring neurons and BF differences exhibited unique clustering at ~0.3 octave intervals, indicative of the frequency band lamina. Other spectral and temporal parameters of the receptive fields were more similar for neighboring neurons than for those at distant sites and the receptive field similarity was larger for neurons with small differences in BF. Furthermore, correlated firing was stronger for neighboring neuron pairs and increased with proximity and decreasing BF difference. Thus, although response selectivities are quite diverse in the IC, spectral, and temporal preference within a local microcircuit are functionally quite similar. This suggests a scheme where local circuits are organized into zones that are specialized for processing distinct spectrotemporal cues.