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Structural plasticity in the dentate gyrus- revisiting a classic injury model

Overview of attention for article published in Frontiers in Neural Circuits, January 2013
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Title
Structural plasticity in the dentate gyrus- revisiting a classic injury model
Published in
Frontiers in Neural Circuits, January 2013
DOI 10.3389/fncir.2013.00017
Pubmed ID
Authors

Julia V. Perederiy, Gary L. Westbrook

Abstract

The adult brain is in a continuous state of remodeling. This is nowhere more true than in the dentate gyrus, where competing forces such as neurodegeneration and neurogenesis dynamically modify neuronal connectivity, and can occur simultaneously. This plasticity of the adult nervous system is particularly important in the context of traumatic brain injury or deafferentation. In this review, we summarize a classic injury model, lesioning of the perforant path, which removes the main extrahippocampal input to the dentate gyrus. Early studies revealed that in response to deafferentation, axons of remaining fiber systems and dendrites of mature granule cells undergo lamina-specific changes, providing one of the first examples of structural plasticity in the adult brain. Given the increasing role of adult-generated new neurons in the function of the dentate gyrus, we also compare the response of newborn and mature granule cells following lesioning of the perforant path. These studies provide insights not only to plasticity in the dentate gyrus, but also to the response of neural circuits to brain injury.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 3 3%
France 1 1%
Russia 1 1%
Japan 1 1%
United States 1 1%
Unknown 89 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 24%
Researcher 20 21%
Student > Master 11 11%
Student > Bachelor 6 6%
Student > Doctoral Student 6 6%
Other 17 18%
Unknown 13 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 40 42%
Neuroscience 16 17%
Medicine and Dentistry 13 14%
Biochemistry, Genetics and Molecular Biology 5 5%
Physics and Astronomy 3 3%
Other 7 7%
Unknown 12 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2013.
All research outputs
#18,331,227
of 22,699,621 outputs
Outputs from Frontiers in Neural Circuits
#934
of 1,209 outputs
Outputs of similar age
#217,972
of 280,682 outputs
Outputs of similar age from Frontiers in Neural Circuits
#119
of 173 outputs
Altmetric has tracked 22,699,621 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,209 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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