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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Matrix Metalloproteinases and Blood-Brain Barrier Disruption in Acute Ischemic Stroke
|
|---|---|
| Published in |
Frontiers in Neurology, January 2013
|
| DOI | 10.3389/fneur.2013.00032 |
| Pubmed ID | |
| Authors |
Shaheen E. Lakhan, Annette Kirchgessner, Deborah Tepper, Aidan Leonard |
| Abstract |
Ischemic stroke continues to be one of the most challenging diseases in translational neurology. Tissue plasminogen activator (tPA) remains the only approved treatment for acute ischemic stroke, but its use is limited to the first hours after stroke onset due to an increased risk of hemorrhagic transformation over time resulting in enhanced brain injury. In this review we discuss the role of matrix metalloproteinases (MMPs) in blood-brain barrier (BBB) disruption as a consequence of ischemic stroke. MMP-9 in particular appears to play an important role in tPA-associated hemorrhagic complications. Reactive oxygen species can enhance the effects of tPA on MMP activation through the loss of caveolin-1 (cav-1), a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability. This review provides an overview of MMPs' role in BBB breakdown during acute ischemic stroke. The possible role of MMPs in combination treatment of acute ischemic stroke is also examined. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 295 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Hong Kong | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 291 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 59 | 20% |
| Student > Bachelor | 43 | 15% |
| Student > Master | 38 | 13% |
| Researcher | 33 | 11% |
| Student > Doctoral Student | 14 | 5% |
| Other | 43 | 15% |
| Unknown | 65 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 59 | 20% |
| Medicine and Dentistry | 47 | 16% |
| Agricultural and Biological Sciences | 38 | 13% |
| Biochemistry, Genetics and Molecular Biology | 32 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 4% |
| Other | 37 | 13% |
| Unknown | 71 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2023.
All research outputs
#20,744,283
of 25,483,400 outputs
Outputs from Frontiers in Neurology
#9,276
of 14,668 outputs
Outputs of similar age
#229,340
of 289,433 outputs
Outputs of similar age from Frontiers in Neurology
#102
of 210 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,668 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,433 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 210 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.