You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Trinucleotide Repeats: A Structural Perspective
|
|---|---|
| Published in |
Frontiers in Neurology, January 2013
|
| DOI | 10.3389/fneur.2013.00076 |
| Pubmed ID | |
| Authors |
Bruno Almeida, Sara Fernandes, Isabel A. Abreu, Sandra Macedo-Ribeiro |
| Abstract |
Trinucleotide repeat (TNR) expansions are present in a wide range of genes involved in several neurological disorders, being directly involved in the molecular mechanisms underlying pathogenesis through modulation of gene expression and/or the function of the RNA or protein it encodes. Structural and functional information on the role of TNR sequences in RNA and protein is crucial to understand the effect of TNR expansions in neurodegeneration. Therefore, this review intends to provide to the reader a structural and functional view of TNR and encoded homopeptide expansions, with a particular emphasis on polyQ expansions and its role at inducing the self-assembly, aggregation and functional alterations of the carrier protein, which culminates in neuronal toxicity and cell death. Detail will be given to the Machado-Joseph Disease-causative and polyQ-containing protein, ataxin-3, providing clues for the impact of polyQ expansion and its flanking regions in the modulation of ataxin-3 molecular interactions, function, and aggregation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 96 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 25% |
| Researcher | 17 | 17% |
| Student > Bachelor | 13 | 13% |
| Student > Master | 10 | 10% |
| Student > Doctoral Student | 4 | 4% |
| Other | 12 | 12% |
| Unknown | 20 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 25 | 25% |
| Agricultural and Biological Sciences | 25 | 25% |
| Medicine and Dentistry | 11 | 11% |
| Neuroscience | 4 | 4% |
| Immunology and Microbiology | 3 | 3% |
| Other | 9 | 9% |
| Unknown | 24 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2021.
All research outputs
#7,185,763
of 22,712,476 outputs
Outputs from Frontiers in Neurology
#4,487
of 11,620 outputs
Outputs of similar age
#80,242
of 280,743 outputs
Outputs of similar age from Frontiers in Neurology
#34
of 210 outputs
Altmetric has tracked 22,712,476 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 11,620 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,743 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 210 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.