Title |
Systems Biology-Derived Discoveries of Intrinsic Clocks
|
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Published in |
Frontiers in Neurology, February 2017
|
DOI | 10.3389/fneur.2017.00025 |
Pubmed ID | |
Authors |
Arthur Millius, Hiroki R. Ueda |
Abstract |
A systems approach to studying biology uses a variety of mathematical, computational, and engineering tools to holistically understand and model properties of cells, tissues, and organisms. Building from early biochemical, genetic, and physiological studies, systems biology became established through the development of genome-wide methods, high-throughput procedures, modern computational processing power, and bioinformatics. Here, we highlight a variety of systems approaches to the study of biological rhythms that occur with a 24-h period-circadian rhythms. We review how systems methods have helped to elucidate complex behaviors of the circadian clock including temperature compensation, rhythmicity, and robustness. Finally, we explain the contribution of systems biology to the transcription-translation feedback loop and posttranslational oscillator models of circadian rhythms and describe new technologies and "-omics" approaches to understand circadian timekeeping and neurophysiology. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 7 | 39% |
Switzerland | 1 | 6% |
Unknown | 10 | 56% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 12 | 67% |
Scientists | 6 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 62 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 15 | 24% |
Student > Ph. D. Student | 11 | 18% |
Researcher | 11 | 18% |
Student > Master | 5 | 8% |
Professor > Associate Professor | 4 | 6% |
Other | 9 | 15% |
Unknown | 7 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 21% |
Biochemistry, Genetics and Molecular Biology | 12 | 19% |
Neuroscience | 7 | 11% |
Medicine and Dentistry | 4 | 6% |
Mathematics | 3 | 5% |
Other | 13 | 21% |
Unknown | 10 | 16% |