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The Optic Canal: A Bottleneck for Cerebrospinal Fluid Dynamics in Normal-Tension Glaucoma?

Overview of attention for article published in Frontiers in Neurology, February 2017
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Title
The Optic Canal: A Bottleneck for Cerebrospinal Fluid Dynamics in Normal-Tension Glaucoma?
Published in
Frontiers in Neurology, February 2017
DOI 10.3389/fneur.2017.00047
Pubmed ID
Authors

Achmed Pircher, Margherita Montali, Jatta Berberat, Luca Remonda, Hanspeter E. Killer

Abstract

To report on the optic canal cross-sectional area (OCA) in Caucasian patients with normal-tension glaucoma (NTG) compared with Caucasian control subjects without known optic nerve (ON) diseases. Retrospective analysis of computed tomographic images of the cranium and orbits in 56 NTG patients (30 females and 26 males; 99 of 112 eyes; mean age 67.7 ± 11.1 years). Fifty-six age- and gender-matched subjects (mean age: 68.0 ± 11.2 years) without known ON diseases served as controls. The OCA at the orbital opening was measured in square millimeters by using the tool "freehand." Statistical analysis was performed by using the independent two-tailed t-test. The mean orbital opening OCA in NTGs measured 14.5 ± 3.5 mm(2) (right OCA: 14.4 ± 3.6 mm(2), left OCA: 14.5 ± 3.4 mm(2)) and in controls measured 18.3 ± 2.6 mm(2) (right OCA: 18.5 ± 2.7 mm(2), left OCA: 18.1 ± 2.5 mm(2)). The difference between NTG and controls was statistically significant (p < 0.000 for the right OCA, p < 0.000 for the left OCA). This study demonstrates narrower OCAs in Caucasian NTG patients compared with Caucasian control subjects without known ON diseases. Narrower OCAs might contribute to a discontinuity of the cerebrospinal fluid flow between the intracranial and orbital subarachnoid space in NTG patients. This might have an influence onto the pathophysiology in NTG.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Other 4 24%
Student > Bachelor 3 18%
Student > Ph. D. Student 1 6%
Student > Master 1 6%
Researcher 1 6%
Other 1 6%
Unknown 6 35%
Readers by discipline Count As %
Medicine and Dentistry 5 29%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Mathematics 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Agricultural and Biological Sciences 1 6%
Other 1 6%
Unknown 7 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2017.
All research outputs
#17,879,732
of 22,955,959 outputs
Outputs from Frontiers in Neurology
#7,114
of 11,842 outputs
Outputs of similar age
#224,478
of 311,210 outputs
Outputs of similar age from Frontiers in Neurology
#85
of 130 outputs
Altmetric has tracked 22,955,959 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,842 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,210 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 130 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.