Title |
Adverse Childhood Experiences Are Linked to Age of Onset and Reading Recognition in Multiple Sclerosis
|
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Published in |
Frontiers in Neurology, June 2017
|
DOI | 10.3389/fneur.2017.00242 |
Pubmed ID | |
Authors |
Michael T. Shaw, Natalie O. Pawlak, Ariana Frontario, Kathleen Sherman, Lauren B. Krupp, Leigh E. Charvet |
Abstract |
Adverse childhood experiences (ACEs) exert a psychological and physiological toll that increases risk of chronic conditions, poorer social functioning, and cognitive impairment in adulthood. To investigate the relationship between childhood adversity and clinical disease features in multiple sclerosis (MS). Sixty-seven participants with MS completed the ACE assessment and neuropsychological assessments as part of a larger clinical trial of cognitive remediation. Adverse childhood experience scores, a measure of exposure to adverse events in childhood, significantly predicted age of MS onset (r = -0.30, p = 0.04). ACEs were also linked to reading recognition (a proxy for premorbid IQ) (r = -0.25, p = 0.04). ACE scores were not related to age, current disability, or current level of cognitive impairment measured by the Symbol Digit Modalities Test (SDMT). Childhood adversity may increase the likelihood of earlier age of onset and poorer estimated premorbid IQ in MS. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Belgium | 1 | 17% |
Unknown | 5 | 83% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 60 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 12 | 20% |
Student > Master | 10 | 17% |
Student > Doctoral Student | 8 | 13% |
Student > Ph. D. Student | 6 | 10% |
Other | 4 | 7% |
Other | 6 | 10% |
Unknown | 14 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 15 | 25% |
Medicine and Dentistry | 7 | 12% |
Nursing and Health Professions | 4 | 7% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Neuroscience | 4 | 7% |
Other | 10 | 17% |
Unknown | 16 | 27% |