Yilong Shan, Sha Tan, Yuge Wang, Kui Li, Lei Zhang, Siyuan Liao, Li Zhou, Zhezhi Deng, Xueqiang Hu, Haiyan Li, Xuejiao Men, Bingjun Zhang, Lisheng Peng, Zhuang Kang, Yan Zou, Zhengqi Lu
Abstract
White matter hyperintensities can be easily identified by brain imaging. Juxtacortical small lesion (JCSL) is a special type of white matter lesion, defined as no greater than 5 mm in diameter and adjacent to the cerebral cortex in location. We notice lately that JCSLs alone may be associated to various neurological symptoms. Here, we design the present study to determine the risk factors for JCSLs and their clinical manifestations in patients in our neurology clinic.
206 participants suffered from neurological disorders and completed magnetic resonance imaging (MRI) examinations were divided into two groups: patients with JCSLs and patients without lesions on MRI. Meanwhile, 129 age- and sex-matched healthy volunteers were also recruited. Laboratory examinations and the phenotypes and distributions of the symptoms of the three groups were compared.
The serum levels of apoB and homocysteine (HCY) were independently related to the appearance of JCSLs and HCY level was also associated with the number of JCSLs. Patients with JCSLs might present with headache, insomnia, and/or anxiety/depression, which were related with the anatomical locations of the lesions.
These data suggest that JCSLs are symptomatic and might in result fromarteriole atherosclerosis, which should raise our attention.
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2017.
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#20,448,386
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#8,924
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Outputs of similar age from Frontiers in Neurology
#151
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