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Intra-Arterial Thrombolysis for Acute Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis

Overview of attention for article published in Frontiers in Neurology, February 2018
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Title
Intra-Arterial Thrombolysis for Acute Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis
Published in
Frontiers in Neurology, February 2018
DOI 10.3389/fneur.2018.00076
Pubmed ID
Authors

Paul S. Page, Nicolas K. Khattar, Andrew C. White, Alexander C. Cambon, Guy N. Brock, Shesh N. Rai, Robert F. James

Abstract

Acute central retinal artery occlusion (CRAO) is a serious ophthalmologic emergency that may result in monocular blindness. To date, studies evaluating intra-arterial thrombolysis (IAT) have not shown a definitive clinical benefit. We have conducted a systematic review with a meta-analysis to effectively evaluate this treatment option. A systematic literature search was focused on studies containing five or more patients undergoing IAT that included a control group treated with standard therapy. Pooled meta-analysis was performed. Five retrospective controlled studies and one randomized clinical trial were identified satisfying all inclusion criteria resulting in the analysis of 236 patients treated with IAT and 255 patients treated with ST. A pooled fixed effects analysis resulted in an estimated odds ratio of 2.52, 95% CI (1.69, 3.77) (P < 0.0001) favoring IAT. IAT is a promising therapeutic option for CRAO with great potential. Further randomized trials are needed to establish a significant benefit and ensure the safety of the intervention.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 7 16%
Researcher 5 11%
Student > Bachelor 5 11%
Other 4 9%
Student > Doctoral Student 3 7%
Other 10 23%
Unknown 10 23%
Readers by discipline Count As %
Medicine and Dentistry 19 43%
Neuroscience 4 9%
Nursing and Health Professions 1 2%
Agricultural and Biological Sciences 1 2%
Sports and Recreations 1 2%
Other 3 7%
Unknown 15 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2018.
All research outputs
#20,465,050
of 23,023,224 outputs
Outputs from Frontiers in Neurology
#8,938
of 11,915 outputs
Outputs of similar age
#292,724
of 331,231 outputs
Outputs of similar age from Frontiers in Neurology
#184
of 252 outputs
Altmetric has tracked 23,023,224 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,915 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 252 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.