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Modulating the Oxytocin System During the Perinatal Period: A New Strategy for Neuroprotection of the Immature Brain?

Overview of attention for article published in Frontiers in Neurology, April 2018
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Title
Modulating the Oxytocin System During the Perinatal Period: A New Strategy for Neuroprotection of the Immature Brain?
Published in
Frontiers in Neurology, April 2018
DOI 10.3389/fneur.2018.00229
Pubmed ID
Authors

Manuela Zinni, Marina Colella, Aline Rideau Batista Novais, Olivier Baud, Jérôme Mairesse

Abstract

Oxytocin is a neurohypophysal hormone known for its activity during labor and its role in lactation. However, the function of oxytocin (OTX) goes far beyond the peripheral regulation of reproduction, and the central effects of OTX have been extensively investigated, since it has been recognized to influence the learning and memory processes. OTX has also prominent effects on social behavior, anxiety, and autism. Interaction between glucocorticoids, OTX, and maternal behavior may have long-term effects on the developmental program of the developing brain subjected to adverse events during pre and perinatal periods. OTX treatment in humans improves many aspects of social cognition and behavior. Its effects on the hypothalamic-pituitary-adrenal axis and inflammation appear to be of interest in neonates because these properties may confer benefits when the perinatal brain has been subjected to injury. Indeed, early life inflammation and abnormal adrenal response to stress have been associated with an abnormal white matter development. Recent investigations demonstrated that OTX is involved in the modulation of microglial reactivity in the developing brain. This review recapitulates state-of-the art data supporting the hypothesis that the OTX system could be considered as an innovative candidate for neuroprotection, especially in the immature brain.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 95 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 16%
Student > Ph. D. Student 13 14%
Student > Master 10 11%
Student > Bachelor 10 11%
Student > Doctoral Student 7 7%
Other 13 14%
Unknown 27 28%
Readers by discipline Count As %
Psychology 19 20%
Medicine and Dentistry 13 14%
Neuroscience 13 14%
Agricultural and Biological Sciences 5 5%
Nursing and Health Professions 4 4%
Other 10 11%
Unknown 31 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2018.
All research outputs
#15,505,836
of 23,043,346 outputs
Outputs from Frontiers in Neurology
#6,847
of 11,945 outputs
Outputs of similar age
#209,019
of 327,991 outputs
Outputs of similar age from Frontiers in Neurology
#167
of 281 outputs
Altmetric has tracked 23,043,346 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,945 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,991 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 281 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.