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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies
|
|---|---|
| Published in |
Frontiers in Neurology, August 2018
|
| DOI | 10.3389/fneur.2018.00549 |
| Pubmed ID | |
| Authors |
Joana R. Guedes, Taotao Lao, Ana L. Cardoso, Joseph El Khoury |
| Abstract |
Chemokines and their receptors have been shown to affect amyloid-β (Aβ) and tau pathologies in mouse models of Alzheimer's disease (AD) by regulating microglia and monocyte-associated neuroinflammation, microglial movement and monocyte recruitment into the brain. These cells in turn can promote and mediate Aβ phagocytosis and degradation and tau phosphorylation. In this review we discuss published work in this field in mouse models of AD and review what is known about the contributions of microglial and monocyte chemokines and their receptors to amyloid and tau pathologies. We focus on the roles of the chemokine/chemokine receptor pairs CCL2/CCR2, CX3CL1/CX3CR1, CCL5/CCR5, CXCL10/CXCR3 and CXCL1/CXCR2, highlighting important knowledge gaps in this field. A full understanding of the functions of chemokines and their receptors in AD may guide the development of novel immunotherapies for this devastating disease. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 138 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 19% |
| Researcher | 20 | 14% |
| Student > Bachelor | 19 | 14% |
| Student > Master | 16 | 12% |
| Student > Doctoral Student | 10 | 7% |
| Other | 20 | 14% |
| Unknown | 27 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 34 | 25% |
| Biochemistry, Genetics and Molecular Biology | 24 | 17% |
| Agricultural and Biological Sciences | 14 | 10% |
| Medicine and Dentistry | 10 | 7% |
| Immunology and Microbiology | 9 | 7% |
| Other | 14 | 10% |
| Unknown | 33 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2018.
All research outputs
#3,171,250
of 23,099,576 outputs
Outputs from Frontiers in Neurology
#2,404
of 12,015 outputs
Outputs of similar age
#65,135
of 331,095 outputs
Outputs of similar age from Frontiers in Neurology
#41
of 298 outputs
Altmetric has tracked 23,099,576 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,015 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,095 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 298 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.