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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Extracellular Vesicles Can Deliver Anti-inflammatory and Anti-scarring Activities of Mesenchymal Stromal Cells After Spinal Cord Injury
|
|---|---|
| Published in |
Frontiers in Neurology, November 2019
|
| DOI | 10.3389/fneur.2019.01225 |
| Pubmed ID | |
| Authors |
Pasquale Romanelli, Lara Bieler, Cornelia Scharler, Karin Pachler, Christina Kreutzer, Pia Zaunmair, Dominika Jakubecova, Heike Mrowetz, Bruno Benedetti, Francisco J. Rivera, Ludwig Aigner, Eva Rohde, Mario Gimona, Dirk Strunk, Sebastien Couillard-Despres |
| Abstract |
Spinal cord injury is characterized by initial neural tissue disruption that triggers secondary damage and extensive non-resolving inflammation, which aggravates loss of function and hinders recovery. The early onset of inflammation following traumatic spinal cord injury underscores the importance of acute intervention after the initial trauma. Injections of mesenchymal stromal cells (MSCs) can reduce inflammation following spinal cord injury. We asked if extracellular vesicles (EVs) can substitute the anti-inflammatory and anti-scarring activities of their parental MSCs in a rat model of contusion spinal cord injury. We report that MSC-EVs were as potent as the parental intact cells in reducing the level of neuroinflammation for up to 2 weeks post-injury. Acute application of EVs after spinal cord injury was shown to robustly decrease the expression of pro-inflammatory cytokines in the spinal cord parenchyma in the very early phase of secondary damage. Moreover, the anti-scarring impact of MSC-EVs was even more efficient than the parental cells. We therefore conclude that anti-inflammatory and anti-scarring activities of MSC application can be mediated by their secreted EVs. In light of their substantial safety and druggability advantages, EVs may have a high potential in early therapeutic treatment following traumatic spinal cord injury. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 69 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 23% |
| Student > Master | 6 | 9% |
| Student > Doctoral Student | 6 | 9% |
| Student > Ph. D. Student | 5 | 7% |
| Student > Bachelor | 4 | 6% |
| Other | 12 | 17% |
| Unknown | 20 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 19% |
| Neuroscience | 9 | 13% |
| Medicine and Dentistry | 7 | 10% |
| Agricultural and Biological Sciences | 3 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 7 | 10% |
| Unknown | 28 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2022.
All research outputs
#2,280,125
of 23,341,064 outputs
Outputs from Frontiers in Neurology
#1,144
of 12,252 outputs
Outputs of similar age
#56,226
of 460,676 outputs
Outputs of similar age from Frontiers in Neurology
#55
of 288 outputs
Altmetric has tracked 23,341,064 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,252 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 460,676 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 288 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.