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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Insular Dysfunction Reflects Altered Between-Network Connectivity and Severity of Negative Symptoms in Schizophrenia during Psychotic Remission
|
|---|---|
| Published in |
Frontiers in Human Neuroscience, January 2013
|
| DOI | 10.3389/fnhum.2013.00216 |
| Pubmed ID | |
| Authors |
Andrei Manoliu, Valentin Riedl, Anselm Doll, Josef Georg Bäuml, Mark Mühlau, Dirk Schwerthöffer, Martin Scherr, Claus Zimmer, Hans Förstl, Josef Bäuml, Afra M. Wohlschläger, Kathrin Koch, Christian Sorg |
| Abstract |
Schizophrenia is characterized by aberrant intrinsic functional connectivity (iFC) within and between intrinsic connectivity networks (ICNs), including the Default Mode- (DMN), Salience- (SN), and Central Executive Network (CEN). The anterior insula (AI) of the SN has been demonstrated to modulate DMN/CEN interactions. Recently, we found that the dependence of DMN/CEN interactions on SN's right AI activity is altered in patients with schizophrenia in acute psychosis and related to psychotic symptoms, indicating a link between aberrant AI, DMN, CEN, and psychosis. However, since structural alterations of the insula are also present during psychotic remission and associated with negative symptoms, impaired AI interaction might be relevant even for psychotic remission and corresponding symptoms. Twelve patients with schizophrenia during psychotic remission (SR) and 12 healthy controls were assessed using resting-state fMRI and psychometric examination. High-model-order independent component analysis of fMRI data revealed ICNs including DMN, SN, and CEN. Scores of iFC within (intra-iFC) and between (inter-iFC) distinct subsystems of the DMN, SN, and CEN were calculated, compared between groups and correlated with the severity of symptoms. Intra-iFC was altered in patients' SN, DMN, and CEN, including decreased intra-iFC in the left AI within the SN. Patients' inter-iFC between SN and CEN was increased and correlated with the severity of negative symptoms. Furthermore, decreased intra-iFC of the left AI correlated with both severity of negative symptoms and increased inter-iFC between SN and CEN. Our result provides first evidence for a relationship between AI dysfunction and altered between-network interactions in schizophrenia during psychotic remission, which is related to the severity of negative symptoms. Together with our previous results, data suggest specific SN/DMN/CEN reorganization in schizophrenia with distinct insular pathways for distinct symptom dimensions. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| United Kingdom | 1 | 1% |
| Australia | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 89 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 20% |
| Researcher | 18 | 19% |
| Student > Master | 11 | 12% |
| Other | 7 | 7% |
| Student > Doctoral Student | 7 | 7% |
| Other | 16 | 17% |
| Unknown | 16 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 21 | 22% |
| Medicine and Dentistry | 20 | 21% |
| Psychology | 16 | 17% |
| Agricultural and Biological Sciences | 3 | 3% |
| Engineering | 2 | 2% |
| Other | 3 | 3% |
| Unknown | 29 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2014.
All research outputs
#14,753,796
of 22,711,242 outputs
Outputs from Frontiers in Human Neuroscience
#4,902
of 7,128 outputs
Outputs of similar age
#175,303
of 280,736 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#645
of 862 outputs
Altmetric has tracked 22,711,242 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,128 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,736 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 862 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.