Title |
COMT Val158Met Polymorphism Is Associated with Verbal Working Memory in Neurofibromatosis Type 1
|
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Published in |
Frontiers in Human Neuroscience, July 2016
|
DOI | 10.3389/fnhum.2016.00334 |
Pubmed ID | |
Authors |
Danielle de Souza Costa, Jonas J. de Paula, Antonio M. Alvim-Soares, Patrícia A. Pereira, Leandro F. Malloy-Diniz, Luiz O. C. Rodrigues, Marco A. Romano-Silva, Débora M. de Miranda |
Abstract |
Neurofibromatosis type I (NF1) is a neurogenetic disease marked by multiple cognitive and learning problems. Genetic variants may account for phenotypic variance in NF1. Here, we investigated the association between the catechol-O-methyltransferase (COMT) Val(158)Met polymorphism and working memory and arithmetic performance in 50 NF1 individuals. A significant association of the COMT polymorphism was observed only with verbal working memory, as measured by the backward digit-span task with an advantageous performance for Met/Met carriers. To study how genetic modifiers influence NF1 cognitive performance might be of importance to decrease the unpredictability of the cognitive profile among NF1 patients. |
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