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Functional Connectivity Abnormalities of Brain Regions with Structural Deficits in Young Adult Male Smokers

Overview of attention for article published in Frontiers in Human Neuroscience, October 2016
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Title
Functional Connectivity Abnormalities of Brain Regions with Structural Deficits in Young Adult Male Smokers
Published in
Frontiers in Human Neuroscience, October 2016
DOI 10.3389/fnhum.2016.00494
Pubmed ID
Authors

Limei Bu, Dahua Yu, Shaoping Su, Yao Ma, Karen M. von Deneen, Lin Luo, Jinquan Zhai, Bo Liu, Jiadong Cheng, Yanyan Guan, Yangding Li, Yanzhi Bi, Ting Xue, Xiaoqi Lu, Kai Yuan

Abstract

Smoking is one of the most prevalent dependence disorders. Previous studies have detected structural and functional deficits in smokers. However, few studies focused on the changes of resting state functional connectivity (RSFC) of the brain regions with structural deficits in young adult smokers. Twenty-six young adult smokers and 26 well-matched healthy non-smokers participated in our study. Voxel-based morphometry (VBM) and RSFC were employed to investigate the structural and functional changes in young adult smokers. Compared with healthy non-smokers, young smokers showed increased gray matter (GM) volume in the left putamen and decreased GM volume in the left anterior cingulate cortex (ACC). Moreover, GM volume in the left ACC has a negative correlation trend with pack-years and GM volume in the left putamen was positively correlated with pack-years. The left ACC and putamen with abnormal volumes were chosen as the regions of interest (ROIs) for the RSFC analysis. We found that smokers showed increased RSFC between the left ACC and right amygdala and between the left putamen and right anterior insula. We revealed structural and functional deficits within the frontostriatal circuits in young smokers, which may shed new insights into the neural mechanisms of smoking.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 14%
Student > Ph. D. Student 3 14%
Student > Master 3 14%
Student > Doctoral Student 1 5%
Researcher 1 5%
Other 2 9%
Unknown 9 41%
Readers by discipline Count As %
Neuroscience 5 23%
Psychology 4 18%
Mathematics 2 9%
Biochemistry, Genetics and Molecular Biology 1 5%
Unknown 10 45%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2016.
All research outputs
#20,344,065
of 22,890,496 outputs
Outputs from Frontiers in Human Neuroscience
#6,551
of 7,173 outputs
Outputs of similar age
#276,841
of 319,862 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#149
of 162 outputs
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