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White Matter Injury after Intracerebral Hemorrhage: Pathophysiology and Therapeutic Strategies

Overview of attention for article published in Frontiers in Human Neuroscience, August 2017
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Title
White Matter Injury after Intracerebral Hemorrhage: Pathophysiology and Therapeutic Strategies
Published in
Frontiers in Human Neuroscience, August 2017
DOI 10.3389/fnhum.2017.00422
Pubmed ID
Authors

Chuanyuan Tao, Xin Hu, Hao Li, Chao You

Abstract

Intracerebral hemorrhage (ICH) accounts for 10%-30% of all types of stroke. Bleeding within the brain parenchyma causes gray matter (GM) destruction as well as proximal or distal white matter (WM) injury (WMI) due to complex pathophysiological mechanisms. Because WM has a distinct cellular architecture, blood supply pattern and corresponding function, and its response to stroke may vary from that of GM, a better understanding of the characteristics of WMI following ICH is essential and may shed new light on treatment options. Current evidence using histological, radiological and chemical biomarkers clearly confirms the spatio-temporal distribution of WMI post- ICH. Although certain types of pathological damage such as inflammatory, oxidative and neuro-excitotoxic injury to WM have been identified, the exact molecular mechanisms remain unclear. In this review article, we briefly describe the constitution and physiological function of brain WM, summarize evidence regarding WMI, and focus on the underlying pathophysiological mechanisms and therapeutic strategies.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 49 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 12%
Student > Doctoral Student 6 12%
Student > Master 5 10%
Student > Bachelor 4 8%
Researcher 4 8%
Other 6 12%
Unknown 18 37%
Readers by discipline Count As %
Medicine and Dentistry 10 20%
Neuroscience 9 18%
Nursing and Health Professions 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 6 12%
Unknown 18 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2017.
All research outputs
#14,077,124
of 22,996,001 outputs
Outputs from Frontiers in Human Neuroscience
#4,307
of 7,185 outputs
Outputs of similar age
#169,270
of 316,635 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#90
of 129 outputs
Altmetric has tracked 22,996,001 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,185 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,635 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.