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MAO-A Phenotype Effects Response Sensitivity and the Parietal Old/New Effect during Recognition Memory

Overview of attention for article published in Frontiers in Human Neuroscience, February 2018
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Title
MAO-A Phenotype Effects Response Sensitivity and the Parietal Old/New Effect during Recognition Memory
Published in
Frontiers in Human Neuroscience, February 2018
DOI 10.3389/fnhum.2018.00053
Pubmed ID
Authors

Robert S. Ross, Andrew Smolen, Tim Curran, Erika Nyhus

Abstract

A critical problem for developing personalized treatment plans for cognitive disruptions is the lack of understanding how individual differences influence cognition. Recognition memory is one cognitive ability that varies from person to person and that variation may be related to different genetic phenotypes. One gene that may impact recognition memory is the monoamine oxidase A gene (MAO-A), which influences the transcription rate of MAO-A. Examination of howMAO-Aphenotypes impact behavioral and event-related potentials (ERPs) correlates of recognition memory may help explain individual differences in recognition memory performance. Therefore, the current study uses electroencephalography (EEG) in combination with genetic phenotyping of theMAO-Agene to determine how well-characterized ERP components of recognition memory, the early frontal old/new effect, left parietal old/new effect, late frontal old/new effect, and the late posterior negativity (LPN) are impacted byMAO-Aphenotype during item and source memory. Our results show that individuals with theMAO-Aphenotype leading to increased transcription have lower response sensitivity during both item and source memory. Additionally, during item memory the left parietal old/new effect is not present due to increased ERP amplitude for correct rejections. The results suggest thatMAO-Aphenotype changes EEG correlates of recognition memory and influences how well individuals differentiate between old and new items.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 19%
Student > Bachelor 4 15%
Student > Ph. D. Student 4 15%
Researcher 3 12%
Other 1 4%
Other 3 12%
Unknown 6 23%
Readers by discipline Count As %
Psychology 10 38%
Neuroscience 6 23%
Agricultural and Biological Sciences 2 8%
Biochemistry, Genetics and Molecular Biology 1 4%
Social Sciences 1 4%
Other 1 4%
Unknown 5 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2018.
All research outputs
#15,325,689
of 26,020,829 outputs
Outputs from Frontiers in Human Neuroscience
#4,107
of 7,784 outputs
Outputs of similar age
#238,677
of 460,200 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#94
of 147 outputs
Altmetric has tracked 26,020,829 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,784 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 460,200 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 147 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.